The Effect of Caffeine on Ischemic Preconditioning
Information source: Radboud University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Caffeine; Ischemic Preconditioning; Ischemia-Reperfusion Injury
Intervention: caffeine (Drug); Technetium-TC99m-labeled Annexin A5 (Drug); ten minutes forearm ischemia (Procedure); ischemic forearm exercise (Procedure)
Phase: N/A
Status: Completed
Sponsored by: Radboud University Official(s) and/or principal investigator(s): Gerard Rongen, MD, Phd, Principal Investigator, Affiliation: Radboud University Nijmegen Medical Centre / Department of pharmacology and Toxicology
Summary
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia
render the (myocardial) muscle more resistant to a subsequent more prolonged period of
ischaemia and reperfusion. Animal studies have provided evidence that adenosine receptor
stimulation is an important mediator of IP. As caffeine is an effective adenosine receptor
antagonist already at concentrations reached after regular coffee consumption, we aimed to
assess whether caffeine impairs IP in humans in vivo. We used a novel and well-validated
model to study IP in humans: 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle.
24 healthy volunteers were randomly assigned to either caffeine (4 mg/kg/iv in 10 minutes)
or saline before a protocol for IP.
Clinical Details
Official title: Caffeine Reduces Acute Ischemic Preconditioning
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind
Primary outcome: Percentual difference in Annexin A5 targetting between the experimental and control arm one and four hours after intravenous injection.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- healthy male volunteers
Exclusion Criteria:
-
Locations and Contacts
Radboud University Nijmegen Medical Centre / Department of Pharmacology and Toxicology, Nijmegen, Gelderland 6500 HB, Netherlands
Additional Information
Related publications: Rongen GA, Oyen WJ, Ramakers BP, Riksen NP, Boerman OC, Steinmetz N, Smits P. Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans. Circulation. 2005 Jan 18;111(2):173-8. Epub 2004 Dec 27.
Starting date: September 2003
Last updated: November 28, 2006
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