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The Effect of Caffeine on Ischemic Preconditioning

Information source: Radboud University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Caffeine; Ischemic Preconditioning; Ischemia-Reperfusion Injury

Intervention: caffeine (Drug); Technetium-TC99m-labeled Annexin A5 (Drug); ten minutes forearm ischemia (Procedure); ischemic forearm exercise (Procedure)

Phase: N/A

Status: Completed

Sponsored by: Radboud University

Official(s) and/or principal investigator(s):
Gerard Rongen, MD, Phd, Principal Investigator, Affiliation: Radboud University Nijmegen Medical Centre / Department of pharmacology and Toxicology

Summary

Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion. Animal studies have provided evidence that adenosine receptor stimulation is an important mediator of IP. As caffeine is an effective adenosine receptor antagonist already at concentrations reached after regular coffee consumption, we aimed to assess whether caffeine impairs IP in humans in vivo. We used a novel and well-validated model to study IP in humans: 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle. 24 healthy volunteers were randomly assigned to either caffeine (4 mg/kg/iv in 10 minutes) or saline before a protocol for IP.

Clinical Details

Official title: Caffeine Reduces Acute Ischemic Preconditioning

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind

Primary outcome: Percentual difference in Annexin A5 targetting between the experimental and control arm one and four hours after intravenous injection.

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- healthy male volunteers

Exclusion Criteria:

-

Locations and Contacts

Radboud University Nijmegen Medical Centre / Department of Pharmacology and Toxicology, Nijmegen, Gelderland 6500 HB, Netherlands
Additional Information

Related publications:

Rongen GA, Oyen WJ, Ramakers BP, Riksen NP, Boerman OC, Steinmetz N, Smits P. Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans. Circulation. 2005 Jan 18;111(2):173-8. Epub 2004 Dec 27.

Starting date: September 2003
Last updated: November 28, 2006

Page last updated: August 20, 2015

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