Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis
Information source: Nanjing University School of Medicine
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Acute Pancreatitis
Intervention: Continuous regional arterial infusion of low molecular weight heparin in celiac trunk (Procedure); General treatment (Other)
Phase: N/A
Status: Recruiting
Sponsored by: Nanjing University School of Medicine Official(s) and/or principal investigator(s): Weiqin Li, Dr, Principal Investigator, Affiliation: Jinling Hospital, School of Medicine, Nanjing University
Overall contact: Weiqin Li, Dr, Phone: +86-025-80860066, Email: kkb9832@gmail.com
Summary
Our animal studies found that continuous regional arterial infusion (CRAI in the celiac
trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global
hemodynamics and restore organ function in a porcine model of severe acute pancreatitis
(SAP,unpublished).
In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the
treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of
these patients.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: coagulation related complicationsPancreatic infection
Secondary outcome: pancreatic necrosisICU duration Hospital duration Mortality
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Symptoms and signs of severe acute pancreatitis according to Atlanta criteria
- Within 3 days from the onset of the disease
- Available for interventional treatment(not sensible to radiocontrast agent)
Exclusion Criteria:
- Pregnant pancreatitis
- Receiving surgery or aspiration before;need of early surgery
- Patients with coagulation disorders
Locations and Contacts
Weiqin Li, Dr, Phone: +86-025-80860066, Email: kkb9832@gmail.com
Department of SICU, Research Institute of General Surgery Jinling Hospital, Nanjing, Jiangsu, China, Nanjing, Jiangsu 210002, China; Recruiting Weiqin Li, Dr, Phone: +86-025-80860066, Email: kkb9832@gmail.com Lu Ke, Dr, Sub-Investigator Luyao Zhang, Dr, Sub-Investigator
Additional Information
Related publications: Lu XS, Qiu F, Li YX, Li JQ, Fan QQ, Zhou RG. Effect of lower-molecular weight heparin in the prevention of pancreatic encephalopathy in the patient with severe acute pancreatitis. Pancreas. 2010 May;39(4):516-9. doi: 10.1097/MPA.0b013e3181c3c954.
Starting date: September 2011
Last updated: December 6, 2013
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