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Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis

Information source: Nanjing University School of Medicine
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acute Pancreatitis

Intervention: Continuous regional arterial infusion of low molecular weight heparin in celiac trunk (Procedure); General treatment (Other)

Phase: N/A

Status: Recruiting

Sponsored by: Nanjing University School of Medicine

Official(s) and/or principal investigator(s):
Weiqin Li, Dr, Principal Investigator, Affiliation: Jinling Hospital, School of Medicine, Nanjing University

Overall contact:
Weiqin Li, Dr, Phone: +86-025-80860066, Email: kkb9832@gmail.com


Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished). In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

coagulation related complications

Pancreatic infection

Secondary outcome:

pancreatic necrosis

ICU duration

Hospital duration



Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.


Inclusion Criteria:

- Symptoms and signs of severe acute pancreatitis according to Atlanta criteria

- Within 3 days from the onset of the disease

- Available for interventional treatment(not sensible to radiocontrast agent)

Exclusion Criteria:

- Pregnant pancreatitis

- Receiving surgery or aspiration before;need of early surgery

- Patients with coagulation disorders

Locations and Contacts

Weiqin Li, Dr, Phone: +86-025-80860066, Email: kkb9832@gmail.com

Department of SICU, Research Institute of General Surgery Jinling Hospital, Nanjing, Jiangsu, China, Nanjing, Jiangsu 210002, China; Recruiting
Weiqin Li, Dr, Phone: +86-025-80860066, Email: kkb9832@gmail.com
Lu Ke, Dr, Sub-Investigator
Luyao Zhang, Dr, Sub-Investigator
Additional Information

Related publications:

Lu XS, Qiu F, Li YX, Li JQ, Fan QQ, Zhou RG. Effect of lower-molecular weight heparin in the prevention of pancreatic encephalopathy in the patient with severe acute pancreatitis. Pancreas. 2010 May;39(4):516-9. doi: 10.1097/MPA.0b013e3181c3c954.

Starting date: September 2011
Last updated: December 6, 2013

Page last updated: August 20, 2015

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