The purpose of this study is to evaluate whether tapentadol (CG5503) prolonged-release (PR)
tablets at doses of 100-250 mg twice daily provide a better pain relief in patients with
moderate to severe chronic pain due to osteoarthritis of the knee than a placebo (a
medication without active substance). In addition the tolerability of CG5503 PR will be
assessed. One third of the patients will receive CG5503 and one third will receive placebo.
For further comparison one third of the patients will receive oxycodone controlled release
(CR) at doses of 20-50 mg twice daily which is an active approved pain medication. Please
note that tapentadol ER (Extended Release) and tapentadol PR (Prolonged Release) are
identical and used interchangeably. This is due to United States of America and European
naming conventions.
Minimum age: 40 Years.
Maximum age: N/A.
Gender(s): Both.
Site 043005, Innsbruck, Austria
Site 043006, Mitterdorf, Austria
Site 043002, Salzburg, Austria
Site 043001, Vienna, Austria
Site 043004, Vienna, Austria
Site 043003, Wiener Neustadt, Austria
Site 385003, Karlovac, Croatia
Site 385001, Osijek, Croatia
Site 385004, Sisak, Croatia
Seite 385005, Zagreb, Croatia
Site 385002, Zagreb, Croatia
Site 049002, Berlin, Germany
Site 049008, Berlin, Germany
Site 049010, Berlin, Germany
Site 049003, Dresden, Germany
Site 049004, Frankfurt, Germany
Site 049007, Hamburg, Germany
Site 049001, Leipzig, Germany
Site 049005, Magdeburg, Germany
Site 049009, Schwerin, Germany
Site 049006, Wiesbaden, Germany
Site 036003, Budapest, Hungary
Site 036005, Budapest, Hungary
Site 036006, Budapest, Hungary
Site 036009, Budapest, Hungary
Site 036008, Debrecen, Hungary
Site 036007, Györj, Hungary
Site 036004, Kecskemet, Hungary
Site 036002, Visegrad, Hungary
Site 039002, Chieti, Italy
Site 039003, Milano, Italy
Site 039004, Pavia, Italy
Site 039001, Perugia, Italy
Site 371002, Bauska, Latvia
Site 371004, Riga, Latvia
Site 371005, Riga, Latvia
Site 031008, Eindhoven, Netherlands
Site 031003, Losser, Netherlands
Site 031006, Oude Pekela, Netherlands
Site 031004, s'Hertogenbosch, Netherlands
Site 031007, Spijkenisse, Netherlands
Site 048007, Bielsko-Biala, Poland
Site 048006, Katowice, Poland
Site 048005, Konskie, Poland
Site 048004, Krakow, Poland
Site 048001, Lublin, Poland
Site 048008, Mielec, Poland
Site 048003, Piekary Slaskie, Poland
Site 048010, Rzeszow, Poland
Site 048009, Warszawa, Poland
Site 048002, Wroclaw, Poland
Site 048011, Wroclaw, Poland
Site 351001, Coimbra, Portugal
Site 351003, Faro, Portugal
Sites 351008, Funchal, Portugal
Site 351005, Guimaraes, Portugal
Site 351004, Lisboa, Portugal
Site 351009, Lisboa, Portugal
Site 351002, Ponta Delgada, Portugal
Site 040001, Bucharest, Romania
Site 040002, Bucharest, Romania
Site 040005, Bucharest, Romania
Site 040006, Bucharest, Romania
Site 040007, Bucharest, Romania
Site 040008, Bucharest, Romania
Site 040009, Bucharest, Romania
Site 040011, Bucharest, Romania
Site 040004, Campulung Muscel Arges County, Romania
Site 040010, Craiova, Dolj County, Romania
Site 421005, Banska Bystrica, Slovakia
Site 421001, Kosice, Slovakia
Site 421003, Poprad, Slovakia
Site 421004, Presov, Slovakia
Site 421002, Rimavska Sobota, Slovakia
Site 034009, Benidorm, Spain
Site 034014, Gran Canaria, Spain
Site 034005, L'Hospitalet de Llobregat, Spain
Site 034007, La roca del Valles, Spain
Site 034015, Malaga, Spain
Site 034008, Mostoles, Spain
Site 034003, Oviedo, Spain
Site 034013, Oviedo, Spain
Site 034002, Petrer, Spain
Site 034016, Sevilla, Spain
Site 034001, Torrelavega, Spain
Site 034012, Valencia, Spain
Site 034004, Vic, Spain
Site 044012, Birmingham, United Kingdom
Site 044004, Blackpool, United Kingdom
Site 044009, Bradford, United Kingdom
Site 044013, Cardiff, United Kingdom
Site 044002, Chesterfield, United Kingdom
Site 044018, Chorley, United Kingdom
Site 044005, Ecclesfield, United Kingdom
Site 044008, Falkirk, United Kingdom
Site 044016, Gardens Reading, United Kingdom
Site 044001, Kenton, United Kingdom
Site 044006, London, United Kingdom
Site 044011, London, United Kingdom
Site 044003, Solihull, United Kingdom
Site 044007, Woolpit, United Kingdom