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Comparison of the Effect of 4th Generation Fluoroquinolones, Gatifloxacin and Moxifloxacin, on Epithelial Healing Following Photorefractive Keratectomy (PRK), A Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)

Information source: Walter Reed Army Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Epithelium, Corneal

Intervention: Moxifloxacin (Drug); Gatifloxacin (Drug)

Phase: N/A

Status: Completed

Sponsored by: Walter Reed Army Medical Center

Official(s) and/or principal investigator(s):
KRAIG S. BOWER, MD, Principal Investigator, Affiliation: Walter Reed Army Medical Center


The purpose of this study is a prospective,double-blinded, randomized trial to compare the rate of healing following PRK after the use of two commercially available 4th generation fluoroquinolones, moxifloxacin and gatifloxacin.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Corneal Epithelial Healing Time


Minimum age: 21 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Manifest refraction spherical equivalent (MSE) of up to -6. 00 diopters (D) at the

spectacle plane with refractive cylinder up to 3. 00D. Exclusion Criteria:

- Concurrent topical or systemic medications that may impair healing including

corticosteroids, antimetabolites, isotretinoin, amiodarone hydrochloride and/ or sumatripin.

- Patients with known sensitivity or inappropriate responsiveness to any of the

medications used in the post-operative course.

- Anterior basement membrane dystrophy.

- History of recurrent epithelial erosion.

- Significant dry eye (symptomatic sith Schirmer <5mm at 5 minutes)

- Other corneal epithelial disorder or healing abnormality

Locations and Contacts

Walter Reed Army Medical Center, Washington, District of Columbia 20307, United States
Additional Information

Last updated: June 26, 2013

Page last updated: August 23, 2015

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