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Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood

Information source: Groningen Research Institute for Asthma and COPD
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Asthma; Healthy

Intervention: allergen inhalation (Behavioral); withdrawal of medication (Behavioral); sputum induction (Procedure)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Groningen Research Institute for Asthma and COPD

Official(s) and/or principal investigator(s):
Dirkje S Postma, prof. MD PhD, Principal Investigator, Affiliation: University Medical Center Groningen, Department of Pulmonology, hanzeplein 1, 9713 GZ Groningen, The Netherlands

Summary

The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine receptor expression versus control subjects. We also want to study the effects of allergen inhalation on adenosine receptor expression in asthmatics. We believe that adenosine receptor expression will be upregulated after allergen inhalation. Both hypotheses are being tested in sputum and peripheral blood.

Clinical Details

Official title: Effects of Allergen Inhalation on Adenosine Receptor Expression and Mast Cell Activation in Peripheral Blood and Sputum of Asthmatics and Healthy Subjects

Study design: Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Asthmatic Subjects - Inclusion Criteria:

- Clinical diagnosis of asthma

- Steroid naive or subjects not using their inhaled steroids for the last 4 weeks,

short-acting beta-agonist for rescue medication

- FEV1 > 70% of predicted

- Positive skin prick test for house dust mite, cat or grass pollen

- PC20 methacholine or histamine < 8 mg/ml

Asthmatic Subjects - Exclusion Criteria:

- Use of systemic steroids in the previous 6 weeks

- Asthma exacerbations in the previous 6 weeks

- Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who

stopped less than 1 year ago

Healthy Subjects - Inclusion Criteria:

- No airway complaints

- FEV1 > 90% of predicted

- Negative skin prick test

- PC20 methacholine or histamine > 8 mg/ml

Healthy Subjects - Exclusion Criteria:

- Use of steroids in the previous 6 weeks

- Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who

stopped less than 1 year ago

Locations and Contacts

University Medical Center Groningen, Department of Pulmonology, Groningen 9713 GZ, Netherlands
Additional Information

Starting date: July 2005
Last updated: March 20, 2007

Page last updated: August 20, 2015

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