This study compares 2 different treatments administered to try to prevent serious bacterial
infections (such as pneumonia) in HIV-positive children. A combination of drugs
(azithromycin plus atovaquone) will be compared to sulfamethoxazole-trimethoprim (SMX/TMP)
alone. This study also evaluates the long-term safety and tolerance of these different
drugs.
SMX/TMP is a commonly prescribed drug for the prevention of bacterial infections. However,
the combination of azithromycin and atovaquone may be safer and more effective than SMX/TMP.
This study compares the 2 treatments.
Minimum age: 3 Months.
Maximum age: 18 Months.
Gender(s): Both.
Ramon Ruiz Arnau Univ Hosp / Pediatrics, Bayamon 00956, Puerto Rico
San Juan City Hosp, San Juan 009367344, Puerto Rico
Univ of Puerto Rico / Univ Children's Hosp AIDS, San Juan 009365067, Puerto Rico
Univ of Alabama at Birmingham - Pediatric, Birmingham, Alabama 35233, United States
Univ of South Alabama, Mobile, Alabama 36604, United States
UCSD Med Ctr / Pediatrics / Clinical Sciences, La Jolla, California 920930672, United States
Long Beach Memorial (Pediatric), Long Beach, California 90801, United States
Cedars Sinai / UCLA Med Ctr, Los Angeles, California 900481804, United States
Children's Hosp of Los Angeles/UCLA Med Ctr, Los Angeles, California 900276016, United States
Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California 905022004, United States
Los Angeles County - USC Med Ctr, Los Angeles, California 90033, United States
UCLA Med Ctr / Pediatric, Los Angeles, California 900951752, United States
Children's Hosp of Oakland, Oakland, California 946091809, United States
UCSF / Moffitt Hosp - Pediatric, San Francisco, California 941430105, United States
Children's Hosp of Denver, Denver, Colorado 802181088, United States
Connecticut Children's Med Ctr, Farmington, Connecticut 060303805, United States
Univ of Connecticut / Farmington, Farmington, Connecticut 06032, United States
Yale Univ Med School, New Haven, Connecticut 06504, United States
Howard Univ Hosp, Washington, District of Columbia 20060, United States
North Broward Hosp District, Fort Lauderdale, Florida 33311, United States
Univ of Florida Gainesville, Gainesville, Florida 32610, United States
Univ of Florida Health Science Ctr / Pediatrics, Jacksonville, Florida 32209, United States
Univ of Miami (Pediatric), Miami, Florida 33161, United States
Palm Beach County Health Dept, Riviera Beach, Florida 33404, United States
Emory Univ Hosp / Pediatrics, Atlanta, Georgia 30306, United States
Med College of Georgia, Augusta, Georgia 30912, United States
Chicago Children's Memorial Hosp, Chicago, Illinois 606143394, United States
Cook County Hosp, Chicago, Illinois 60612, United States
Univ of Chicago Children's Hosp, Chicago, Illinois 606371470, United States
Univ of Illinois College of Medicine / Pediatrics, Chicago, Illinois 60612, United States
Earl K Long Early Intervention Clinic, New Orleans, Louisiana 70112, United States
Tulane Univ / Charity Hosp of New Orleans, New Orleans, Louisiana 701122699, United States
Johns Hopkins Hosp - Pediatric, Baltimore, Maryland 212874933, United States
Univ of Maryland at Baltimore / Univ Med Ctr, Baltimore, Maryland 21201, United States
Boston City Hosp / Pediatrics, Boston, Massachusetts 02118, United States
Children's Hosp of Boston, Boston, Massachusetts 021155724, United States
Baystate Med Ctr of Springfield, Springfield, Massachusetts 01199, United States
Univ of Massachusetts Med School, Worcester, Massachusetts 016550001, United States
Children's Hosp of Michigan, Detroit, Michigan 48201, United States
Univ of Mississippi Med Ctr, Jackson, Mississippi 39213, United States
Cooper Hosp - Univ Med Ctr / UMDNJ - New Jersey Med Schl, Camden, New Jersey 08103, United States
UMDNJ - Robert Wood Johnson Med School / Pediatrics, New Brunswick, New Jersey 089030019, United States
Saint Joseph's Hosp and Med Ctr/UMDNJ - New Jersey Med Schl, Newark, New Jersey 07103, United States
Univ of Medicine & Dentistry of New Jersey / Univ Hosp, Newark, New Jersey 071032714, United States
Children's Hosp at Albany Med Ctr, Albany, New York 12208, United States
Bronx Lebanon Hosp Ctr, Bronx, New York 10457, United States
Montefiore Med Ctr Adolescent AIDS Program, Bronx, New York 10467, United States
SUNY - Brooklyn, Brooklyn, New York 11203, United States
Children's Hosp Pact Prog / Children's Hosp of Buffalo, Buffalo, New York 14222, United States
North Shore Univ Hosp, Great Neck, New York 11021, United States
Schneider Children's Hosp, New Hyde Park, New York 11040, United States
Bellevue Hosp / New York Univ Med Ctr, New York, New York 10016, United States
Beth Israel Med Ctr / Pediatrics, New York, New York 10003, United States
Columbia Presbyterian Med Ctr, New York, New York 10032, United States
Cornell Univ Med College, New York, New York 10021, United States
Harlem Hosp Ctr, New York, New York 10037, United States
Incarnation Children's Ctr / Columbia Presbyterian Med Ctr, New York, New York 10032, United States
Metropolitan Hosp Ctr, New York, New York 10029, United States
Mount Sinai Med Ctr / Pediatrics, New York, New York 10029, United States
Univ of Rochester Med Ctr, Rochester, New York 146420001, United States
Univ of Rochester Medical Center, Rochester, New York 14642, United States
State Univ of New York at Stony Brook, Stony Brook, New York 117948111, United States
SUNY Health Sciences Ctr at Syracuse / Pediatrics, Syracuse, New York 13210, United States
Duke Univ Med Ctr, Durham, North Carolina 277103499, United States
Columbus Children's Hosp, Columbus, Ohio 432052696, United States
Children's Hosp of Philadelphia, Philadelphia, Pennsylvania 191044318, United States
Saint Christopher's Hosp for Children, Philadelphia, Pennsylvania 191341095, United States
Med Univ of South Carolina, Charleston, South Carolina 294253312, United States
Saint Jude Children's Research Hosp of Memphis, Memphis, Tennessee 381052794, United States
Vanderbilt Univ Med Ctr, Nashville, Tennessee 372322581, United States
Hermann Hosp / Univ Texas Health Science Ctr, Houston, Texas 77030, United States
Texas Children's Hosp / Baylor Univ, Houston, Texas 77030, United States
Children's Hosp of the King's Daughters, Norfolk, Virginia 23507, United States
Med College of Virginia, Richmond, Virginia 23219, United States
Children's Hospital & Medical Center / Seattle ACTU, Seattle, Washington 981050371, United States
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Ngo LY, Yogev R, Dankner WM, Hughes WT, Burchett S, Xu J, Sadler B, Unadkat JD. Pharmacokinetics of azithromycin administered alone and with atovaquone in human immunodeficiency virus-infected children. The ACTG 254 Team. Antimicrob Agents Chemother. 1999 Jun;43(6):1516-9.
Perrier M, Schwarz T, Gonzalez O, Brounts S. Squamous cell carcinoma invading the right temporomandibular joint in a Belgian mare. Can Vet J. 2010 Aug;51(8):885-7.