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Detection of Celiac Disease in Patients With Hypothyroidism

Information source: University of Vermont
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Celiac Disease; Hypothyroidism; Celiac Sprue; Malabsorption

Phase: N/A

Status: Completed

Sponsored by: University of Vermont

Official(s) and/or principal investigator(s):
Richard Zubarik, MD, Principal Investigator, Affiliation: University of Vermont


The study evaluates whether hypothyroid patients requiring elevated doses of levothyroxine to maintain a euthyroid state are at increased risk of having celiac disease. It also attempts to determine if there is a threshold level of levothyroxine needed to maintain a euthyroid state in patients with hypothyroidism that should prompt serologic testing for celiac disease.

Clinical Details

Official title: Detection of Celiac Disease in Patients With Hypothyroidism

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome: presence of celiac disease

Secondary outcome:

Symptoms associated with celiac disease

medication adjustment

Detailed description: This study is looking at whether hypothyroid patients who require above 125 mcg/day (or >1. 5mcg/kg/day) of levothyroxine are more likely to have celiac disease than those who require smaller doses. It also looks to see if the prevalence of celiac disease in hypothyroid patients who require elevated doses of levothyroxine is high enough to warrant screening in that population.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Patients with the diagnosis of hypothyroidism that require thyroid replacement

therapy. Exclusion Criteria:

- Surgical resection of thyroid tissue, neck irradiation, radioactive iodine therapy,

prior medical treatment with lithium, methimazole, propylthiouracil, ethionamide, amiodarone, or sunitinib, prior serologic testing for celiac disease.

Locations and Contacts

Fletcher Allen Health Care, Burlington, Vermont 05405, United States
Additional Information

Related publications:

Collins D, Wilcox R, Nathan M, Zubarik R. Celiac disease and hypothyroidism. Am J Med. 2012 Mar;125(3):278-82. doi: 10.1016/j.amjmed.2011.09.003.

Starting date: March 2012
Last updated: December 5, 2014

Page last updated: August 23, 2015

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