Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate
Information source: University of Mississippi Medical Center
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypertension
Intervention: Metoprolol (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: University of Mississippi Medical Center Official(s) and/or principal investigator(s):
Deborah Minor, PharmD, Principal Investigator, Affiliation: University of Mississippi Medical Center
Overall contact:
Cathy Adair, RN, CCRC, Phone: 601-815-1338, Email: cadair@medicine.umsmed.edu
Summary
The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour
ambulatory blood pressure characteristics and basal metabolic rates in patients with
hypertension.
Clinical Details
Official title: Comparative Effects of Nebivolol Versus Metoprolol on 24-Hour Blood Pressures and Basal Metabolic Rate: An Open-Label Study
Study design: Treatment, Open Label, Active Control, Factorial Assignment, Safety/Efficacy Study
Primary outcome: Primary outcome is pre- and post-treatment ambulatory blood pressure, basal metabolic rate, and quality of life.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 18 years old or older
- currently be treated at a University of MS Medical Center Internal Medicine Clinics
- currently taking metoprolol succinate for hypertension
- have their hypertension controlled (<140/90).
Exclusion Criteria:
- uncontrolled hypertension
- severe renal or moderate hepatic impairment
- currently taking CYP 2D6 inducers/inhibitors
- recent stroke (less than 6 months)
- recent myocardial infarction (less than 6 months)
- congestive heart failure
- diagnosed obstructive sleep apnea
- atrial fibrillation
- arm circumference >50 cm
Locations and Contacts
Cathy Adair, RN, CCRC, Phone: 601-815-1338, Email: cadair@medicine.umsmed.edu
University of Mississippi Medical Center, Jackson, Mississippi 39216, United States; Recruiting
Additional Information
Starting date: January 2009
Ending date: January 2010
Last updated: July 1, 2009
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