This study aims to investigate whether patients switching their backbone from Kivexa to
Truvada, who already have raised total cholesterol prior to switching, have an improvement in
their total cholesterol after 12 weeks of treatment. If an improvement is demonstrated the
study aims to show whether this has a beneficial effect on the patient's overall
cardiovascular risk and long term prognosis.
At Baseline, subjects will be randomized 1: 1 to one of two treatment groups:
Treatment Group 1: switch to Atripla Treatment Group 2: Continuation of previous stable HAART
regimen of Kivexa + EFV Initiation of treatment with study drugs must take place within 24
hours after Baseline visit. At Week 12, subjects in Treatment Group 2 (continuation of Kivexa
and EFV regimen) will switch to Atripla. Treatment in both groups will continue through Week
24
Inclusion Criteria:
- Equal to or greater to 18 years old
- Plasma HIV RNA less than 50 copies/mL equal to or greater than 12 weeks prior to
Screening
- Stable HAART regimen of Kivexa + EFV for equal to or greater than 24 weeks prior to
Screening
- Documented confirmed raised total cholesterol greater than or equal to 5. 2 mmol/L for
last two consecutive tests (at least 4 weeks apart) with the last result less than or
equal to 4 weeks prior to Screening
- Subject willing to continue current unmodified HAART for 12 weeks if randomized to
Group 2
- Subjects requiring concomitant lipid regulating therapy must be established on a
stable dose/frequency greater than or equal to 12 weeks prior to Screening and be
expected to remain stable in dose and frequency throughout the treatment phase of the
study
- Adequate renal function by calculated creatinine clearance greater than or equal to 60
mL/min according to the Cockcroft Gault formula
- Negative serum pregnancy test (females of childbearing potential only i. e., not
surgically sterile or at least 2 years post-menopausal)
- Hepatic Total Bilirubin ≤ 1. 5 mg/dL
- Adequate haematologic function of absolute neutrophil count ≥ 1000/mm3, platelets ≥
25,000/mm3, Haemoglobin ≥ 8. 0g/dL
- Women of childbearing potential (WOCBP) must be using two methods of contraception to
avoid pregnancy throughout the study and for up to 12 weeks after the last dose of
study drugs in such a manner that the risk of pregnancy is minimized. Subjects may
choose two (barrier plus highly effective method - see section 7. 8 for further
discussion) of the birth control methods listed below:
- Hormonal birth control drugs
- Male or female condoms with or without spermicidal gels
- Diaphragm cervical cap with or without spermicidal gels
- Intrauterine device
- Female subjects who utilize hormone contraceptive as one of their birth control
methods must have used the same methods for at least 3 months prior to study dosing
- Female subjects who are postmenopausal for less than 2 years are required to have FSH
greater or equal to 40 mIU/mL. If the FSH is less than 40 mIU/mL, the subject must
agree to use highly effective method of birth control (as described above) to
participate in the study
- Male subjects who are sexually active must be willing to use effective barrier
contraception (e. g. condom with spermicide) during heterosexual intercourse from
screening through completion of the study and continuing for up to 12 weeks after the
last dose of study drugs
- Life expectancy greater to or equal to 1 year
- The ability to understand and sign a written informed consent form, which must be
obtained prior to initiation of study procedures
Exclusion Criteria:
- Pregnant or lactating subjects
- Previous treatment with emtricitabine (FTC), tenofovir DF (TDF) or adefovir dipivoxil
(ADV)
- Known hypersensitivity to emtricitabine (FTC), tenofovir DF (TDF), efavirenz (EFV) or
Truvada
- Documented resistance to any of the study drugs (either genotypic or phenotypic)
- Severe hepatic impairment
- Hepatic transaminases (AST and ALT) greater or equal to 5 times the upper limit of
normal (ULN)
- Subjects receiving ongoing therapy with any of the medications that are
contraindicated with any of the study drugs. Administration of any of these
medications must be discontinued at least 30 days prior to the Baseline visit and for
the duration of the study period. The full list of disallowed medications can be found
in appendix 7.
- Active, serious infections (other than HIV infection) requiring parenteral antibiotic
therapy within 15 days prior to screening
- Prior history of significant renal or bone disease
- Any current known clinical or symptomatic laboratory parameter of GSI grade 4.
Asymptomatic grade 4 abnormalities will be permitted at the discretion of the
Investigator if deemed clinically appropriate (excluding AEs and laboratory parameters
mentioned elsewhere in the inclusion/exclusion criteria). Abnormalities deemed
insignificant by the Investigator must be discussed with the Sponsor prior to
enrollment.
- Malignancy other than cutaneous Kaposi sarcoma (KS) or basal cell carcinoma. Subjects
with biopsy-confirmed cutaneous KS are eligible, but must not have received any
systemic therapy for KS within 30 days of baseline and are not anticipated to require
systemic therapy during the study
- Current alcohol or substance use judged by the investigator to potentially interfere
with subject study compliance
- Subjects currently taking part in any other clinical trial using an investigational
product, with the exception of studies where the treatment studied has been stopped
for more than 1 month
- Any other clinical condition or prior therapy that, in the opinion of the
investigator, would make the subject unsuitable for the study or unable to comply with
the dosing requirements
