Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management
Information source: National Institute on Drug Abuse (NIDA)
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Opiate-Related Disorders; Cocaine-Related Disorders
Intervention: Contingency Management (Behavioral); Methadone dose (Drug); Contingency management/Noncontingent incentives (Behavioral); Methadone (Drug)
Phase: Phase 2
Status: Recruiting
Sponsored by: National Institute on Drug Abuse (NIDA) Official(s) and/or principal investigator(s):
Kenzie Preston, PhD, Principal Investigator, Affiliation: NIDA Intramural Research Program
Overall contact:
Kenzie Preston, PhD, Phone: 410-550-1639, Email: kpreston@intra.nida.nih.gov
Summary
The purpose of this study is to determine if simultaneous abstinence from heroin and cocaine
can be elicited by combining two approaches: flexible methadone dosing and voucher-based
contingency management in which patients earn incentives for cocaine abstinence.
Clinical Details
Official title: Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Dose Comparison, Parallel Assignment
Primary outcome: abstinence from cocaine and heroin
Secondary outcome: time to relapsePsychological and psychosocial outcome HIV Risk Behaviors QT interval urine microalbuminuria blood lipid profile Quality of Life Substance Dependence methadone plasma and saliva concentration cortisol and prolactin levels
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- physical dependence on opiates; requiring treatment for cocaine use; able to attend
clinic seven days per week
Exclusion Criteria:
- medical or psychiatric conditions for which methadone is contraindicated; pregnancy;
inability to give informed consent
Locations and Contacts
Kenzie Preston, PhD, Phone: 410-550-1639, Email: kpreston@intra.nida.nih.gov
NIDA Intramural Research Program, Baltimore, Maryland 21224, United States; Recruiting
Kenzie Preston, PhD, Principal Investigator
Additional Information
Starting date: December 2004
Ending date: January 2012
Last updated: June 19, 2008
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