AMP as a Better Delivery System of Adenosine

Condition(s) targeted: Ischemia

Intervention: Adenosine (Drug); Adenosine Mono Phosphate (AMP) (Drug)

Phase: N/A

Status: Suspended

Sponsored by: Vanderbilt University

Official(s) and/or principal investigator(s):
Italo Biaggioni, M.D., Principal Investigator, Affiliation: Vanderbilt University

Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks. The problem in using adenosine is that it is taken up by cells and, therefore, very little of the adenosine we give by vein or in the artery actually reaches the tissue. We propose to use AMP as a way to improve delivery of adenosine. AMP is inactive by itself, but is converted to adenosine in tissue. We hope that by giving AMP we will increase levels of adenosine in tissue. To see if this is true, we will give either adenosine or AMP into the forearm artery while we measure how much adenosine reaches the forearm tissue.

Official title: Use of AMP to Improve Tissue Delivery of Adenosine

Study design: Other, Non-Randomized, Single Blind (Subject), Active Control, Crossover Assignment, Efficacy Study

Primary outcome:

Interstitial adenosine levels

Forearm blood flow

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Healthy volunteers

- Age 18-65

- Non smokers

Exclusion Criteria:

- Smokers

- Any chronic disease

Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States

Starting date: October 2003
Ending date: January 2008
Last updated: December 22, 2007