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AMP as a Better Delivery System of Adenosine

Information source: Vanderbilt University
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Ischemia

Intervention: Adenosine (Drug); Adenosine Mono Phosphate (AMP) (Drug)

Phase: N/A

Status: Suspended

Sponsored by: Vanderbilt University

Official(s) and/or principal investigator(s):
Italo Biaggioni, M.D., Principal Investigator, Affiliation: Vanderbilt University


Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks. The problem in using adenosine is that it is taken up by cells and, therefore, very little of the adenosine we give by vein or in the artery actually reaches the tissue. We propose to use AMP as a way to improve delivery of adenosine. AMP is inactive by itself, but is converted to adenosine in tissue. We hope that by giving AMP we will increase levels of adenosine in tissue. To see if this is true, we will give either adenosine or AMP into the forearm artery while we measure how much adenosine reaches the forearm tissue.

Clinical Details

Official title: Use of AMP to Improve Tissue Delivery of Adenosine

Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)

Primary outcome:

Interstitial adenosine levels

Forearm blood flow


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Healthy volunteers

- Age 18-65

- Non smokers

Exclusion Criteria:

- Smokers

- Any chronic disease

Locations and Contacts

Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
Additional Information

Starting date: October 2003
Last updated: February 2, 2015

Page last updated: August 20, 2015

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