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Evaluation of Therapeutic Management in ESBL-infected Patients or Carriers by Providing and Sharing a Free Tool - the "ESBL toolKIT"and Interventional Study of a Prospective Cohort of HIV+ Patients Searching for Possible Sexual Transmission Factors in ESBL Carriers

Information source: Centre Hospitalier Universitaire de Nice
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: AIDS Patients

Intervention: HIV seropositive patients (Other)

Phase: N/A

Status: Recruiting

Sponsored by: Centre Hospitalier Universitaire de Nice

Official(s) and/or principal investigator(s):
MONDAIN Véronique, Ph, Principal Investigator, Affiliation: Service d'Infectiologie - Hôpital Archet - 151 route St Ginestière - 06 202 Nice

Overall contact:
MONDAIN Véronique, Ph, Phone: +33492035466, Email: mondain.v@chu-nice.fr


Bacterial resistance to antibiotics is a major public health problem. The epidemiology of enteric bacteria including E. coli is changing rapidly with the global spread of a resistance mechanism type beta-lactamase extended spectrum (ESBL), responsible for resistance to almost all penicillins and cephalosporins. The resistance is up to 75% for Quinolones, 67% for Cotrimoxazole and 30-50% for Aminoglycosides. The main phenomena causing this problem are:

- The selection pressure by antibiotics, in their use in humans or animals

- The hand transmission via the digestive reservoir (faeces)

- Easy spread of resistance mechanism in Enterobacteriaceae due to transferable genetic

support (plasmid) In this context, we decided to implement a cross-border study to improve and accelerate the management, diagnosis and treatment of patients with ESBL in close collaboration between medical and paramedical staff in hospitals, laboratories and private medical offices. The objective of this study is to standardize diagnostic and therapeutic measures allowing a better and rapid treatment of patients and thus prevent the appearence of ESBL bacteria in the PACA region and Liguria by providing a tool : The "Kit ESBL". The " ESBL ToolKIT" (also translated into Italian) includes:

- Information on epidemiological data

- A checklist edited for extra-hospital use (private practitioners, health care units

other than hospitals)

- A checklist edited for hospital use

- A leaflet BMR for the patient explaining the problematic as well as hygiene measures

- Therapeutical protocols for hospital use and extra hospital use

- An sample letter for the attending physician

The objective of this prospective multicenter cohort study is to evaluate the use of this kit, and to measure its impact on:

- The prescription of appropriate antibiotics

- The measures taken to prevent man to man transmission

- The quality of information provided to the patient

In this context we are also performing a multicentre prospective interventional cohort of HIV+ patients searching for possible sexual transmission factors in ESBL (extended-spectrum ß-lacatamase-producing bacteria) carriers. We will also try to determine if other sexually transmitted infections associated (syphilis, gonorrhea and chlamydia) are contributing factors to ESBL carriage. So far there is no data documented on ESBL-carriage in a population of HIV-positive patients.

Clinical Details

Official title: Evaluation of Therapeutic Management in ESBL-infected Patients or Carriers by Providing and Sharing a Free Tool - the "ESBL toolKIT" and Interventional Study of a Prospective Cohort of HIV+ Patients Searching for Possible Sexual Transmission Factors in ESBL (Extended-spectrum -lacatamase-producing Bacteria) Carriers

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Primary outcome: enterobacteria ESBLs


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Age > 18

- HIV+ patient of the hospital's outpatient clinic

- Signature of informed consent

- Affiliation of the Social Security system

Exclusion criteria

- Vulnerable Persons: minor patient, wardship (tutelage), no liberty to act and speak

- Pregnancy and lactation: a urine pregnancy test will be performed for women of

childbearing age. Results will be reported by the physician selected by the patient

Locations and Contacts

MONDAIN Véronique, Ph, Phone: +33492035466, Email: mondain.v@chu-nice.fr

MONDAIN, Nice, Alpes-Maritimes 06200, France; Recruiting
MONDAIN véronique, Ph, Phone: +492035466, Email: mondain.v@chu-nice.fr
MONDAIN Véronique, Ph, Principal Investigator
Additional Information

Starting date: November 2013
Last updated: December 10, 2013

Page last updated: August 23, 2015

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