Atorvastatin and Sympathetic Activity in Chronic Kidney Disease
Information source: UMC Utrecht
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Stable Chronic Kidney Disease; Hypertension
Intervention: Atorvastatin (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: UMC Utrecht
Summary
Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity
which appears to contribute to the pathogenesis of hypertension and cardiovascular organ
damage. Experimental studies and some clinical studies have shown that statin therapy can
reduce central sympathetic activity. Blockade of the renin-angiotensin system (RAS), which
is standard treatment for CKD, is known to lower sympathetic activity.
The investigators hypothesize that adding a statin for 6 weeks to RAS blockade would further
lower sympathetic activity in hypertensive stage 2-4 CKD patients.
Methods: In ten stable CKD patients who are on chronic treatment with renin-angiotenis
blockers, blood pressure and sympathetic activity (quantified by assessment of muscle
sympathetic nerve activity, MSNA) will be assessed at baseline and 6 weeks after
atorvastatin 20mg/day added.
Ten other CKD patients will serve as time control and will be studied twice with an interval
of 6 weeks without any change in medication, to quantify within subject reproducibility.
Clinical Details
Official title: Atorvastatin Reduces Sympathetic Activity in Patients With Chronic Kidney Disease
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Sympathetic activity
Detailed description:
see above
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- stable chronic kidney disease
- Hypertension
Exclusion Criteria:
- renal replacement therapy
- pregnancy
- diabetes mellitus
Locations and Contacts
University Medical Center utrecht, Utrecht 3584CX, Netherlands
Additional Information
Starting date: August 2009
Last updated: December 8, 2010
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