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Atorvastatin and Sympathetic Activity in Chronic Kidney Disease

Information source: UMC Utrecht
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Stable Chronic Kidney Disease; Hypertension

Intervention: Atorvastatin (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: UMC Utrecht

Summary

Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity which appears to contribute to the pathogenesis of hypertension and cardiovascular organ damage. Experimental studies and some clinical studies have shown that statin therapy can reduce central sympathetic activity. Blockade of the renin-angiotensin system (RAS), which is standard treatment for CKD, is known to lower sympathetic activity. The investigators hypothesize that adding a statin for 6 weeks to RAS blockade would further lower sympathetic activity in hypertensive stage 2-4 CKD patients. Methods: In ten stable CKD patients who are on chronic treatment with renin-angiotenis blockers, blood pressure and sympathetic activity (quantified by assessment of muscle sympathetic nerve activity, MSNA) will be assessed at baseline and 6 weeks after atorvastatin 20mg/day added. Ten other CKD patients will serve as time control and will be studied twice with an interval of 6 weeks without any change in medication, to quantify within subject reproducibility.

Clinical Details

Official title: Atorvastatin Reduces Sympathetic Activity in Patients With Chronic Kidney Disease

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Sympathetic activity

Detailed description: see above

Eligibility

Minimum age: 18 Years. Maximum age: 85 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- stable chronic kidney disease

- Hypertension

Exclusion Criteria:

- renal replacement therapy

- pregnancy

- diabetes mellitus

Locations and Contacts

University Medical Center utrecht, Utrecht 3584CX, Netherlands
Additional Information

Starting date: August 2009
Last updated: December 8, 2010

Page last updated: August 23, 2015

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