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Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects?

Information source: Frankel, Amylynne, M.D.
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Psoriasis

Intervention: Acitretin 17.5 mg/day (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Frankel, Amylynne, M.D.

Overall contact:
Amylynne J Frankel, MD, Phone: 212-241-3288, Email: Amylynne.Frankel@mssm.edu

Summary

Psoriasis is a chronic skin disorder with a prevalence of approximately 1-3% worldwide. At present, there is no curative therapy available and the clinical course is unpredictable, but in the majority of cases psoriasis is a chronically remitting and relapsing disease. Several clinical subtypes of psoriasis exist with differences in manifestations and skin areas involved.

Chronic stable plaque psoriasis (Psoriasis Vulgaris) is the commonest form of the disease, accounting for 85-90% of cases. The circumscribed infiltrated skin lesions are scaly and erythematous and often symmetrically distributed over the body. Several types of palliative therapies exist. The therapies are either topical or systemic. The severity of chronic plaque psoriasis is often determined by the percentage of body surface area (BSA) involved. For mild, moderate and severe chronic plaque psoriasis with BSA involvement of up to 20%, initial therapy is topical. Phototherapy and numerous systemic therapies are usually indicated when more than 20% of skin is affected.

Severe plaque-type psoriasis requires systemic and long-term therapy in order to induce and maintain remission. Acitretin 25mg/day combined with a phototherapy regimen is a standard treatment that provides clinically significant efficacy, however many patients experience tolerability issues due to retinoid-related adverse events. Retinoid-related adverse events include but are not limited to: alopecia, dry mucus membranes, pruritus, photosensitivity, elevation of liver enzymes, elevation of serum triglycerides, cholesterol and decrease of HDL, arthralgias, myalgias, eye irritation, blepharitis, photophobia, conjunctivitis, headaches, nausea, anemia and leukemia. Reducing the acitretin dose from 25mg/day to 17. 5mg/day may provide improved tolerability without compromising efficacy.

The purpose of this study is to ascertain if reducing the acitretin dose from 25mg/day to 17. 5mg/day will provide improved tolerability without compromising efficacy.

Clinical Details

Official title: An Open Label Trial to Show That Subjects With Severe Plaque-Type Psoriasis Receiving Acitretin 25 mg/Day And Stabilized On A Photochemotherapy Regimen Who Are Experiencing Retinoid-Related Adverse Events, Benefit From A Reduction In Acitretin Dose to 17.5 mg/Day, While Maintaining Comparable Efficacy Along With Improved Tolerability

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Improvement in psoriasis

Secondary outcome: Subjective efficacy/tolerability

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Male or female subjects 18 years of age or older.

- Surgically sterile females. Females who have had a hysterectomy or oophorectomy or

completed menopause (post-menopausal for at least 1 year) are allowed. Men must agree to use 2 forms of birth control (eg condoms, spermicide).

- Stabilized on a phototherapy regimen for 4 weeks.

- Compliant with acitretin dosing at 25 mg/day and experiencing retinoid-related

adverse events which, in the clinical judgement of the investigator, may benefit from a reduction in dose to 17. 5 mg/day.

- Able to complete the study and to comply with the study instructions.

- Adherence to alcohol avoidance during acitretin therapy and for 2 months after

discontinuation of acitretin.

- Subjects must be willing to not donate blood during the study as well as 3 years

following completion of this study.

- Capable of understanding and willing to provide signed and dated written voluntary

informed consent (and any local or national authorization requirements) before any protocol specific procedures are performed.

Exclusion Criteria:

- Uncontrolled hypertriglyceridemia.

- Guttate, erythrodermic, or pustular psoriasis.

- Severely impaired hepatic function, > 3 times the upper limit of normal and the

clinical investigator's judgment.

- Use of systemic immunosuppressant agents (eg. Methotrexate, cyclosporine,

thioguanine, azathioprine, alefacept, egalizumab, corticosteroids) within 4 weeks of baseline and throughout the study.

- Topical vitamin A, vitamin D or analogue preparations, or anthralin within 2 weeks of

study initiation.

- History of known or suspected intolerance to any of the ingredients of the

investigational study product.

- Used over the counter (non-prescription) medications or herbal remedies within 2

weeks of dosing, unless agreed upon as not clinically relevant by the principal investigator.

- Participated in a previous study of the same study product.

- Currently using any medication which, in the opinion of the investigator, may affect

the evaluation of the study product or place the subject at undue risk.

- Currently suffering from any disease or condition which, in the opinion of the

investigator, may affect the evaluation of the study product or place the subject at undue risk.

- Any major illness within 30 days before screening examination.

- Considered immunocompromised.

- A clinically relevant history of or current evidence of abuse of alcohol or other

drugs.

- Use of any investigational drugs or treatments during the study or within 4 weeks of

the baseline visit.

- Women of child-bearing potential (see inclusion criteria).

Locations and Contacts

Amylynne J Frankel, MD, Phone: 212-241-3288, Email: Amylynne.Frankel@mssm.edu

Mount Sinai Clinical Trials, New York, New York 10065, United States; Recruiting
Giselle K Singer, MD, Phone: 212-241-3288, Email: Giselle.Singer@mssm.edu
Amylynne J Frankel, MD, Principal Investigator
Additional Information

Starting date: October 2010
Last updated: June 21, 2011

Page last updated: February 07, 2013

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