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Effect of Aldosterone Blockade on Arterial Compliance

Information source: Wolfson Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Arterial Stiffness; Arterial Elasticity

Intervention: Spironolactone (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Wolfson Medical Center

Summary

The present study investigated the long-term (12 months) effect of spironolactone treatment on glucose homeostasis, metabolic parameters and vascular properties.

Clinical Details

Official title: Effect of Aldosterone Blockade on Metabolic Parameters and Arterial Compliance

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Eligibility

Minimum age: 45 Years. Maximum age: 85 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. patients with type 2 diabetes mellitus Exclusion Criteria: 1. history of unstable angina, myocardial infarction (MI), cerebrovascular accident (CVA) 2. major surgery within the six months preceding entrance to the study 3. unbalanced endocrine disease 4. any disease that might affect absorption of medications 5. plasma creatinine >2. 5 mg/dl 6. elevation of liver enzymes to more that twice the upper normal limit 7. plasma potassium levels >5. 5 mg/dl

Locations and Contacts

Wolfson Medical Center, Holon 58100, Israel
Additional Information

Starting date: May 2004
Last updated: March 26, 2010

Page last updated: August 23, 2015

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