Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation

Condition(s) targeted: Infertility

Intervention: mild ovarian stimulation (Procedure); conventional ovarian stimulation (Procedure)

Phase: Phase 1/Phase 2

Status: Recruiting

Sponsored by: National and Kapodistrian University of Athens

Overall contact:
Charalampos S Siristatidis, Senior Lecturer, Phone: 6932294994, Ext: 0030, Email: harrysiri@yahoo.gr

The investigators will examine the balance between IVF success in terms of outcome parameters, including patient discomfort, complications and cost, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.

Official title: Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: Number / rate of participants with ongoing pregnancy

Secondary outcome:

Number/rate of participants whom the IVF cycle was cancelled

clinical pregnancy rate

Minimum age: 25 Years. Maximum age: 43 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- poor responders

- indication for IVF

- regular cycling patients

- BMI 19-29

Exclusion Criteria:

- contraindication for clomiphene citrate use or to GnRH antagonists

- BMI > 30

Charalampos S Siristatidis, Senior Lecturer, Phone: 6932294994, Ext: 0030, Email: harrysiri@yahoo.gr

3rd Department of Obstetrics & Gynecology, Assisted Reproduction Unit, Athens, Chaidari 12462, Greece; Recruiting
Siristatidis, Email: harrysiri@yahoo.gr
Charalampos Chrelias, Assistant Professor, Sub-Investigator
Dimitrios Kassanos, Associate Professor, Sub-Investigator

Starting date: March 2011
Last updated: March 21, 2011