Carbachols Headache-Inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients
Information source: Danish Headache Center
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Headache
Intervention: Carbachol (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Danish Headache Center Official(s) and/or principal investigator(s):
Henrik Schytz, MD, Principal Investigator, Affiliation: Danish Headache Center
Overall contact:
Henrik Schytz, MD, Phone: +4528761824, Email: hewisc01@glo.regionh.dk
Summary
The purpose of this study is to test if carbachol infusion induces headache in migraine
subjects as well as intra- and extra-cerebral vasodilatation.
Clinical Details
Official title: Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-Cerebral Vessels During and After Infusion of Carbachol
Study design: Basic Science, Randomized, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment, Pharmacodynamics Study
Primary outcome: Headache response after Carbachol infusion
Detailed description:
To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra-
and extra-cerebral vasodilatation in a double-blinded study
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Migraine without aura
- Weight 50-100 kg
Exclusion Criteria:
- Other significant diseases
- Migraine 5 days prior to experiment
Locations and Contacts
Henrik Schytz, MD, Phone: +4528761824, Email: hewisc01@glo.regionh.dk
Danish Headache Center, Glostrup 2600, Denmark; Recruiting
Henrik Schytz, MD, Phone: +4528761824, Email: hewisc01@glo.regionh.dk
Henrik Schytz, MD, Principal Investigator
Additional Information
Starting date: August 2007
Ending date: October 2008
Last updated: August 29, 2008
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