The Effect and Safety of Low Dose Nebulized Epinephrine in Croup
Information source: Seoul National University Hospital
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Croup; Epinephrine Neublizer Treatment
Intervention: conventional dose epinephrine (Drug); low dose epinephrine (Drug)
Phase: Phase 4
Status: Not yet recruiting
Sponsored by: Seoul National University Hospital
Summary
Croup is common illness presenting emergency department with dyspnea. The main treatment for
croup is nebulized L-epinephrine and steroid. The study for the dose of nebulized
L-epinephrine is restricted that the study of comparision between racemic epinephrine and
L-epinephrine.
The investigators conducted this study to compare the effectiveness of low dose
L-epinephrine with conventional dose L-epinephrine.
Clinical Details
Official title: The Effect and Safety of Low Dose Nebulized Epinephrine in the Treatment of Croup
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Primary outcome: the difference of Westley croup score between baseline and 30 minutes after neublized treatment
Secondary outcome: the incidence of use of additional neublized treatmentWestley croup score the side effect of epinephrine respiratory rate, oxygen saturation health care utilization- length of stay in emergency department, admission rate, revisit dut to croup symptom treatment failure rebound effect
Eligibility
Minimum age: 6 Months.
Maximum age: 5 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- croup children between 6 month and 5 years old
- Westley croup score between 3 and 11
Exclusion Criteria:
- underlying lung or heart disase
- contra indication to dexamethasone
- immune deficient state
- preterm birth
- previous intubation or apnea history
Locations and Contacts
Seoul National University Bundang Hospital, Gyeonggi-do 463-707, Korea, Republic of
Additional Information
Starting date: September 2012
Last updated: August 9, 2012
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