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Use of Atropine in Tredmill Stress Testing

Information source: HaEmek Medical Center, Israel
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chest Pain

Intervention: Atropine (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: HaEmek Medical Center, Israel


The aim of this study is to evaluate the Safety and feasibility of atropine added during treadmill stress testing in patients with chronotropic incompetence or poor exercise capacity. Our hypothesis is that we can increase heart rate by using atropin in these patients, so we will achieve more conclusive results.

Clinical Details

Official title: Safety and Feasibility of Atropine Added During Treadmill Stress Testing in Patients With Chronotropic Incompetence or Poor Exercise Capacity.

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Primary outcome: 1- To characterize patients who can't achieve target heart rate at treadmill exercise test.2- To evaluate atropine added during treadmill stress testing in order to increase heart rate and achieave conclusive test.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.


Inclusion Criteria:

- Patients with chest pain without evidence of ischemia eligible for exercise test.

- Age> 18 years old

Exclusion Criteria: Absolute:

- Patients with LBBB

- Unstable Angina

- Recent Myocardial Infarction

- Un controlled Arrythmia

- Congestive heart faliure

- Severe symptomatic valvular heart disease

- Acute Pulmonary Embolism

- Acute perimyocarditis

- Acute aortic dissection


- Lt main stenosis

- Severe hypertention (Systolic> 200 mmHg; Diastolic > 100 mmHg)

- Cardiomyopathy

- Obstructiove abnormalities

- Psychiatric disorders

- High degree AV Block

Locations and Contacts

Heart Institute, Ha'Emek Medical Center, Afula 18100, Israel
Additional Information

Starting date: December 2007
Last updated: July 24, 2015

Page last updated: August 20, 2015

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