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Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion

Information source: Seoul St. Mary's Hospital
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pericardial Effusion

Intervention: Colchicine (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Seoul St. Mary's Hospital

Official(s) and/or principal investigator(s):
Yong Seog Oh, MD, Principal Investigator, Affiliation: Seoul St. Mary's Hospital

Overall contact:
Sung Hwan Kim, professor, Phone: 82-2-2258-1141, Email: sunghwan@catholic.ac.kr

Summary

The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.

Clinical Details

Official title: Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: recurrence of atrial arrhythimia

Secondary outcome: recurrence of atrial arrhythimia

Detailed description: RFCA was started as a rhythm control of atrial fibrillation about 10 years before and the superiority of RFCA to medical treatment has been continuously reporting, so RFCA is globally performed nowadays. Acute pericardial effusion could occur during RFCA as complication, that might be developed to cardiac tamponade needed immediate pericardiocentesis. The inflammation developed after pericardiocentesis might be associated with the recurrences of atrial fibrillation, it could be presumed by the frequent occurrence of atrial fibrillation after open-heart surgery. The inflammation can be suppressed by administration of colchicine and the effects of colchicine have been proven to decrease the development of atrial fibrillation.

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients needed to pericardiocentesis during RFCA for paroxysmal or persistent atrial

fibrillation. Exclusion Criteria:

- Hypersensitivity on Colchicine

- The existence of intra-cardiac thrombus on trans-esophageal echocardiography

- Pregnancy

Locations and Contacts

Sung Hwan Kim, professor, Phone: 82-2-2258-1141, Email: sunghwan@catholic.ac.kr

Seoul St Mary's Hospital, Seoul, Seo Cho Gu 137-701, Korea, Republic of; Recruiting
In Ae Jung, coordinator
Additional Information

Starting date: July 2014
Last updated: October 8, 2014

Page last updated: August 20, 2015

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