Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea

Condition(s) targeted: OSA; Rocuronium; Neuromuscular Blockade; Hypoxic Ventilatory Response; CPAP

Intervention: Rocuronium (Drug)

Phase: N/A

Status: Enrolling by invitation

Sponsored by: Malin Jonsson Fagerlund

Official(s) and/or principal investigator(s):
Malin Jonsson Fagerlund, MD, PhD, Principal Investigator, Affiliation: Karolinska University Hospital and Karolinska Institutet

This study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with OSA before and after 3 month of CPAP treatment.

Official title: Effect of Partial Neuromuscular Blockade by Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea-before and After Three Month CPAP Treatment. A Non-randomized, Non-blinded Study.

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Primary outcome: Hypoxic ventilatory response

Secondary outcome:

Hypercarbic ventilatory response

Hypoxic ventilatory response

Hypoxic ventilatory response during acute CPAP treatment

Hypercarbic ventilatory response

Hypercarbic ventilatory response during acute CPAP treatment

Upper airway obstruction

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Male with diagnosed moderate OSA (AHI 15-30), untreated, but planned for CPAP

treatment. Healthy except for OSA and well controlled tablet treated hypertension where the treatment has not been changed during the last 3 month. None smokers. 18-70 years old. BMI <35. Exclusion Criteria:

- If they don´t fit the inclusion criteria

Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital, Stockholm se-17176, Sweden

Starting date: May 2012
Last updated: October 6, 2014