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Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea

Information source: Karolinska University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: OSA; Rocuronium; Neuromuscular Blockade; Hypoxic Ventilatory Response; CPAP

Intervention: Rocuronium (Drug)

Phase: N/A

Status: Enrolling by invitation

Sponsored by: Malin Jonsson Fagerlund

Official(s) and/or principal investigator(s):
Malin Jonsson Fagerlund, MD, PhD, Principal Investigator, Affiliation: Karolinska University Hospital and Karolinska Institutet

Summary

This study describe the effect of partial neuromuscular blockade of rocuronium on the acute hypoxic ventilatory response in patients with OSA before and after 3 month of CPAP treatment.

Clinical Details

Official title: Effect of Partial Neuromuscular Blockade by Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea-before and After Three Month CPAP Treatment. A Non-randomized, Non-blinded Study.

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Primary outcome: Hypoxic ventilatory response

Secondary outcome:

Hypercarbic ventilatory response

Hypoxic ventilatory response

Hypoxic ventilatory response during acute CPAP treatment

Hypercarbic ventilatory response

Hypercarbic ventilatory response during acute CPAP treatment

Upper airway obstruction

Eligibility

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Male with diagnosed moderate OSA (AHI 15-30), untreated, but planned for CPAP

treatment. Healthy except for OSA and well controlled tablet treated hypertension where the treatment has not been changed during the last 3 month. None smokers. 18-70 years old. BMI <35. Exclusion Criteria:

- If they donĀ“t fit the inclusion criteria

Locations and Contacts

Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital, Stockholm se-17176, Sweden
Additional Information

Starting date: May 2012
Last updated: October 6, 2014

Page last updated: August 23, 2015

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