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Norepinephrine Weaning in Septic Patients

Information source: Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Septic Shock

Intervention: norepinephrine infused at the clinician's discretion (Device); norepinephrine infused under computerized fuzzy logic control (Device)

Phase: Phase 4

Status: Completed

Sponsored by: Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence

Summary

The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. The investigators goal was to reduce the duration of poorly controlled hemodynamic status.

Clinical Details

Official title: Continuous Administration of Norepinephrine Assisted by Fuzzy Logic Assisted Control in Septic Shock Patients

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Time to shock resolution defined as cessation of vasopressor support

Secondary outcome: 28 days survival, total amount of norepinephrine infused, duration of mechanical ventilation, and length of stay in the ICU

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Septic shock

Exclusion Criteria:

- Less than 18 years

- Pregnancy

- Weight above 135 kg

- Requirement for continuous epinephrine infusion

- Severe head injury, stroke, a comatose state following cardiac arrest

Locations and Contacts

RĂ©animation, Bobigny, Seine-Saint-Denis 93000, France
Additional Information

Starting date: November 2004
Last updated: September 30, 2008

Page last updated: August 23, 2015

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