Cortico-Cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
Information source: University of Wisconsin, Madison
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy
Phase: N/A
Status: Recruiting
Sponsored by: University of Wisconsin, Madison Official(s) and/or principal investigator(s):
Robert Pearce, MD, PhD, Principal Investigator, Affiliation: University of Wisconsin, Madison
Overall contact:
Andrea Maser, MSW, Phone: (608) 256-1901, Email: alm@clinicaltrials.wisc.edu
Summary
The aim of the proposed research is to measure the effect of drug-induced sedation on the
functional connectivity between brain regions as indicated by EEG signal transmission within
the human brain. The results of this study will help to identify the neurophysiological
correlates of changes in conscious experience that occur during drug-induced sedation.
Clinical Details
Official title: Cortico-Cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
Study design: Case Control, Prospective
Primary outcome: Defining the neurophysiological conditions that are necessary for conscious experience.
Secondary outcome: Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia.
Detailed description:
In the proposed experiments cortical areas will be stimulated using low frequency,
low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during
wakefulness and during drug-induced responsive sedation and unresponsive sedation.
Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the
temporal and spatial characteristics of evoked responses and induced rhythms over the
cortex.
Eligibility
Minimum age: 18 Years.
Maximum age: 35 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Healthy right-handed men
- Aged 18-35
- Non-smokers
- No metallic implants
Exclusion Criteria:
- Younger than 18 or over the age of 35.
Locations and Contacts
Andrea Maser, MSW, Phone: (608) 256-1901, Email: alm@clinicaltrials.wisc.edu
University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, United States; Recruiting
Andrea Maser, MS, Phone: 608-265-6544
Additional Information
Starting date: July 2008
Ending date: May 2009
Last updated: August 12, 2008
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