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Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery

Information source: Lawson Health Research Institute
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Vasopressor Agents; Endarterectomy, Carotid; Echocardiography, Transesophageal

Intervention: Comparison of Effects of Phenylephrine and Norepinephrine (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Lawson Health Research Institute

Official(s) and/or principal investigator(s):
Rosemary A Craen, MD, FRCPC, Principal Investigator, Affiliation: Associate Professor University of Western Ontario

Overall contact:
Rosemary A Craen, MD, FRCPC, Phone: (519) 663-3022, Email: rosemary.craen@lhsc.on.ca

Summary

This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.

Clinical Details

Official title: Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Cross-Clamping During Carotid Endarterectomy Under General Anesthesia

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double-Blind

Primary outcome: Myocardial ischemia measures by transesophageal echocardiography and ST segment analyses

Secondary outcome: Myocardial ischemia measures by cardiac troponin I

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Elective carotid endarterectomy under general anesthesia

- > 18 years old

- Written informed consent

Exclusion Criteria:

- Contraindication to general anesthesia

- Contraindication to transesophageal anesthesia

- esophageal disease

- esophageal stricture

- history of esophageal or gastric bleeding

- esophageal anatomic abnormality

- past esophageal or gastric surgery

- severe dysphagia

Locations and Contacts

Rosemary A Craen, MD, FRCPC, Phone: (519) 663-3022, Email: rosemary.craen@lhsc.on.ca

University Hospital, LHSC, London, Ontario N6A 5A5, Canada; Recruiting
Rosemary A Craen, MD, FRCPC, Phone: (519) 663-3022, Email: Rosemary.Craen@lhsc.on.ca
Rosemary A Craen, MD, FRCPC, Principal Investigator
Additional Information

Starting date: February 2006
Last updated: February 17, 2006

Page last updated: August 23, 2015

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