The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure
Information source: Radboud University
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Heart Failure, Congestive
Intervention: phentolamine (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Radboud University Official(s) and/or principal investigator(s):
Cees J Tack, MD, PhD, Principal Investigator, Affiliation: Radboud University
Overall contact:
Marc E.R. Gomes, MD, Phone: +31-24-3614533/3616550, Email: m.gomes@cardio.umcn.nl
Summary
The activity of the sympathetic nervous system seems to influence the uptake (and handling)
of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is
increased seem to inhibit/reduce forearm glucose uptake. Inversely a decrease in sympathetic
activity seems to increase glucose uptake. This study analyzes the effect of alfa-adrenergic
receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose
uptake in patients with increased sympathetic activity (patients with chronic heart
failure).
Clinical Details
Official title: The Effect of a-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure
Study design: Non-Randomized, Open Label, Active Control, Single Group Assignment
Primary outcome: change in glucose uptake
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Heart failure of at least New York Heart Association (NYHA) class II
- Left ventricular ejection fraction (LVEF) <= 40%
- Age 18-75 years
Exclusion Criteria:
- Alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol)
- Tricyclic antidepressants
- Warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed)
- Hospitalisation in 6 weeks prior to the study
- Any change in medication in 6 weeks prior to the study
- Unstable angina
- Orthopnoea
- Known chronic disease of the autonomic nervous system
- Diabetes mellitus
- Oedema of the lower extremities, complicating the insertion of a venous catheter in
a vein on the foot
Locations and Contacts
Marc E.R. Gomes, MD, Phone: +31-24-3614533/3616550, Email: m.gomes@cardio.umcn.nl
Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, Netherlands; Recruiting
Marc ER Gomes, MD, Phone: 31-24-3614533/3616550, Email: m.gomes@cardio.umcn.nl
Marc ER Gomes, MD, Sub-Investigator
Alexandra H Mulder, MD, Sub-Investigator
Freek WA Verheugt, MD, PhD, Sub-Investigator
Paul Smits, MD, PhD, Sub-Investigator
Cees J Tack, MD, PhD, Principal Investigator
Louise Bellersen, MD, Sub-Investigator
Additional Information
Starting date: August 2005
Last updated: August 30, 2007
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