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The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables

Information source: Regional Hospital Holstebro
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Essential Hypertension

Intervention: Spironolactone (Drug); Placebo (Other); Amiloride (Drug)

Phase: N/A

Status: Completed

Sponsored by: Regional Hospital Holstebro

Official(s) and/or principal investigator(s):
Solveig K Matthesen, MD, Principal Investigator, Affiliation: Departments of medical research and medicine


The investigators wish to study the effect of retaining potassium. The participants have essential hypertension. The test substances are Amiloride, Spironolactone and placebo. The participants will ingest tablets for 28 days before being examined. We will perform a 24 hours urine collection, 24-hours bloodpressure measurement, blood and urine samples and we also examine the patient using a SphygmoCor.

Clinical Details

Official title: The Effect of Amiloride and Spironolactone on Renovascular and Cardiovascular Variables in Patients With Essential Hypertension in a Doubleblinded, Randomized, Placebo-controlled, Crossover Study.

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: Bloodpressure

Detailed description: Purpose of the study is to examine the effect of amiloride and spironolactone on 1. Renal function (GFR, u-AQP2, u-ENaCĪ², u-cAMP, u-PGE2, CH20, FENa, FEK), 2. Pulsewave velocity, augmentation index central bloodpressure, 3. Vasoactive hormones (PRC, AngII, Aldo, AVP, ANP, BNP and Endot), and 4. Ambulatory bloodpressure


Minimum age: 40 Years. Maximum age: 70 Years. Gender(s): Both.


Inclusion Criteria:

- hypertension,

- BMI 18,5-30,

- non-smoker

Exclusion Criteria:

- Smoking

- Not using contraceptives

- Other illnesses

- Drug or alcohol abuse

Locations and Contacts

Departments of medical research and medicine, Holstebro 7500, Denmark
Additional Information

Starting date: August 2010
Last updated: August 19, 2015

Page last updated: August 23, 2015

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