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Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery

Information source: Yonsei University
Information obtained from ClinicalTrials.gov on October 04, 2010
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Laparoscopic Nephrectomy; Postoperative IV-PCA

Intervention: Ondansetron (Drug); Ramosetron (Drug); Palonosetron (Drug)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Yonsei University

Summary

The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic laparoscopic surgery.

Clinical Details

Official title: Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Prevention

Primary outcome:

severity of nausea

the number of vomiting

Eligibility

Minimum age: 20 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- ASA I or II

- Patients aged (20-65 yr) Undergoing Laparoscopic Nephrectomy

- Patients who want a patient-controlled IV analgesia (IV-PCA)

Exclusion Criteria:

- History of allergy or hypersensitivity to 5-HT3 antagonist

- History of severe postoperative nausea/vomiting

- Prolonged QT interval on preoperative EKG

- Hypokalemia, Hypomagnesemia

- Intestinal obstruction

- Pregnant female or breast feeding mother

Locations and Contacts

Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, Korea, Republic of
Additional Information

Starting date: August 2010
Last updated: July 23, 2010

Page last updated: October 04, 2010

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