Nebulized Ceftazidime and Amikacin in Ventilator Associated Pneumonia
Information source: Groupe Hospitalier Pitie-Salpetriere
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pneumonia
Intervention: ceftazidime and amikacin (Drug); ceftazidime and amikacin (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Groupe Hospitalier Pitie-Salpetriere Official(s) and/or principal investigator(s): Jean-Jacques Rouby, MD, PhD, Principal Investigator, Affiliation: La Pitie-Salpetriere hospital
Summary
Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated
pneumonia often resistant to antibiotics. In experimental models, nebulization of
antibiotics delivers high lung tissue concentrations of antibiotics in infected lungs and
increases lung bacterial killing. The aim of the study is to assess the efficiency of
nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas
aeruginosa in ventilated patients.
Clinical Details
Official title: Assessment of Efficiency of Nebulized Ceftazidime and Amikacin in Treatment of Ventilator Associated Pneumonia Caused by Pseudomonas Aeruginosa
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Bacterial killing
Secondary outcome: Changes of lung aeration
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Male or female >18 years old, ventilator associated pneumonia caused by pseudomonas
aeruginosa
- Written informed consent provided by the relatives
Exclusion Criteria:
- Pseudomonas aeruginosa resistant to ceftazidime and amikacin
- Pseudomonas aeruginosa pneumonia associated with other infections requiring
intravenous treatment
- Severe septic shock and severe hypoxemia
- Allergy to ceftazidime or amikacin
Locations and Contacts
Intensive care unit, Department of anesthesiology, La pitie-Salpetriere hospital, Paris 75013, France
Additional Information
Starting date: October 2004
Last updated: November 5, 2008
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