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Community-Acquired Pneumonia - Study on the Initial Treatment With Antibiotics of Lower Respiratory Tract Infections

Information source: UMC Utrecht
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Community-acquired Pneumonia

Intervention: Preferred empirical treatment (Other)

Phase: N/A

Status: Completed

Sponsored by: UMC Utrecht

Official(s) and/or principal investigator(s):
Marc J. Bonten, MD PhD, Principal Investigator, Affiliation: UMC Utrecht


The purpose of this study is to compare the cost(effectiveness) of three existing antibiotic strategies for patients with community-acquired pneumonia admitted to the hospital, but not the ICU.

Clinical Details

Official title: Antibiotic Treatment of Community-acquired Pneumonia: a Prospective Comparison of Dutch Guideline Advices.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Day 90 Mortality

Secondary outcome:

Length of intravenous antibiotic treatment

Length of hospital stay



Health care costs and non-health care costs


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- All patients admitted to one of the participating hospitals needing treatment for

CAP, not being admitted to the ICU are eligible for study inclusion.

- Admission is defined as hospital stay for more than 24 hours.

Exclusion Criteria:

- Patients who are readmitted with CAP within 2 weeks after a previous episode are not


- Patients with cystic fibrosis are not eligible.

Locations and Contacts

Medical Center Alkmaar, Alkmaar, Netherlands

AMC Amsterdam, Amsterdam, Netherlands

Amphia Hospital Breda, Breda, Netherlands

Kennemer Gasthuis, Haarlem, Netherlands

Spaarne Hospital, Hoofddorp, Netherlands

Diakonessenhuis Utrecht, Utrecht, Netherlands

UMC Utrecht, Utrecht, Netherlands

Additional Information

Dutch website of study progress

Starting date: February 2011
Last updated: April 22, 2014

Page last updated: August 23, 2015

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