The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS)
Information source: Medical College of Wisconsin
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cyclic Vomiting Syndrome
Phase: N/A
Status: Enrolling by invitation
Sponsored by: Medical College of Wisconsin Official(s) and/or principal investigator(s): B Li, MD, Principal Investigator, Affiliation: Medical College of Wiconsin
Summary
This is a study with the principle goal being to learn about the use of L-Carnitine and
CoQ10, two vitamin supplements that are currently being used to treat Cyclic Vomiting
Syndrome, largely initiated by parents. We want to learn how effective these supplements
are compared to standard treatment, at what dose, and what onset of action in order to
initiate future prospective study on these supplements.
Clinical Details
Official title: Co-Enzyme Q10, L-Carnitine and Amitriptyline Usage in Cyclic Vomiting Syndrome (CVS): A Research Study
Study design: Observational Model: Family-Based, Time Perspective: Prospective
Primary outcome: How two vitamin supplements are being used to treat cyclic vomiting syndrome
Secondary outcome: How effective these supplements appear to be compared to standard treatment
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 3 discrete episodes of vomiting
- normal health between episodes
- stereotypical clinical pattern
- no abnormal test results to account for vomiting (see exclusion criteria)
Exclusion Criteria:
- abnormal UGI with small bowel follow-through revealing an anatomic anomaly,
inflammatory or obstructive
- Significantly abnormal endoscopic biopsies (moderate to severe esophagitis, H.
pylori)
- Abnormal abdominal ultrasound revealing hydronephrosis, cholelithiasis, pancreatitis
- Positive screening for endocrine disorder (diabetic ketoacidosis, Addison's)
- Positive screening for inborn errors of metabolism (hypoglycemia, lactic acidosis,
hyperammonemia, organic acidemia, amino aciduria, elevated beta-ALA, porphobilinogen)
Locations and Contacts
Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, United States
Additional Information
Cyclic Vomiting Syndrome Association
Starting date: October 2007
Last updated: January 3, 2014
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