Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery
Information source: Aga Khan University
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Intervertebral Disc Prolapse
Intervention: Pregabalin (Drug); Gabapentin (Drug)
Phase: Phase 3
Status: Completed
Sponsored by: Aga Khan University Official(s) and/or principal investigator(s): Mohsin Qadeer, FCPS, Principal Investigator, Affiliation: The Aga Khan University Hospital, Karachi, Pakistan
Summary
Pregabalin is claimed to have superior analgesic effect at lower doses and better
pharmacological profile as compared to gabapentin esp. in perioperative pain control after
major surgeries like intervertebral disc surgery.
The investigators found that pregabalin is equivalent to gabapentin for relief of
post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.
Clinical Details
Official title: Gabapentin vs. Pregabalin for Post Operative Pain in Lumbar Microdiscectomy: a Randomized Controlled Trial.
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Supportive Care
Primary outcome: Pain
Eligibility
Minimum age: 30 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 30-60 years age
- Any gender
- elective micro discectomy for intervertebral disc prolapse
Exclusion Criteria:
1. micro discectomy at two or more vertebral levels,
2. Instrumentation i. e. pedicle screw fixation, hooks etc.,
3. history of steroids or alcohol use,
4. Multiple co-morbids i. e. renal failure, chronic liver disease,
5. use of anticonvulsant drugs,
6. Spinal deformity,
7. Obesity (BMI >30), 8) inability to understand and respond VAS and
9) patients with known allergy to GABA analogues.
Locations and Contacts
The Aga Khan University Hospital, Karachi, Sind 75300, Pakistan
Additional Information
Starting date: February 2011
Last updated: April 22, 2014
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