The purpose of this study is to compare levels of vitamin C in the blood over the 24 hour
period following a single 1000 mg dose of vitamin C from ascorbic acid, calcium ascorbate
and placebo.
Minimum age: 18 Years.
Maximum age: 60 Years.
Gender(s): Both.
Inclusion Criteria:
- Healthy as determined by laboratory results and medical history
- Females not of child bearing potential
- BMI 18-30 kg/m2
- Agrees to consume a low vitamin C diet
- Non-smoker or ex-smoker >1 year
Exclusion Criteria:
- Pregnant, breastfeeding, or planning to become pregnant during the trial
- Alcohol >2 drinks per day; alcohol or drug abuse within the past year
- Cardiac conditions
- Duodenal ulcer or gastric ulcer, gastritis, hiatus hernia, or gastroesophageal reflux
disease (GERD) within past 3 months
- History irritable bowel syndrome, malabsorption or significant GI disease
- History of kidney stones
- Use of medications known to interact with vitamin C
- Use of supplements containing vitamin C
- Use of anticoagulants (warfarin), barbiturates, tetracycline antibiotics,
beta-blockers, cyclosporine, prednisone, tricyclic antidepressants, diuretics and
nitrate medications
- History of or current diagnosis of cancer
- Uncontrolled hypertension
- History of diabetes, renal disease and/or liver disease
- Unstable psychiatric disorder
- History of or current immunocompromise
- History of hemochromatosis or hemoglobinopathies
- Participation in a clinical research trial <30 days
- Use of acute medication w/in 72 hours of intervention
- Unstable medications <90 days
- Abnormal liver function
- Serum creatinine > 1. 5 x upper limit of normal (ULN)
- Anemia of any etiology
- Blood donation w/in the last 2 months
- Allergy or sensitivity to test articles, foods or beverages provided during the study
- Cognitive impairment and/or unable to give informed consent