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Rate Control in Atrial Fibrillation

Information source: Tehran University of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Rapid Ventricular Response Atrial Fibrillation

Intervention: Propranolol (Drug); Metoprolol (Drug); Verapamil (Drug); Diltiazem (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Tehran University of Medical Sciences


Rate control in atrial fibrillation is a usual battle in emergency departments. Oral medications have a natural superiority to intravenous ones because they are easy-to-use and decrease the workload in busy emergency departments. This study wants to find an effective oral medication for rate control in rapid ventricular response atrial fibrillation. Propranolol and Metoprolol, Diltiazem and Verapamil are compared in patients with a stable hemodynamic status.

Clinical Details

Official title: Oral Propranolol, Diltiazem, Metoprolol and Verapamil in Atrial Fibrillation Rate Control in Patients With Stable Hemodynamic Status

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Primary outcome: Rate less than 100 per minute

Secondary outcome:

Drugs adverse effects

Unstability in hemodynamic


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Age more than 18 years old

- Stability in hemodynamic

Exclusion Criteria:

- Systolic blood pressure less than 90 mm Hg

- Altered mental status attributable to rapid ventricular response atrial fibrillation

- Acute pulmonary edema attributable to rapid ventricular response atrial fibrillation

- Chest pain attributable to rapid ventricular response atrial fibrillation

- Allergy to Propranolol or Metoprolol or Verapamil or Diltiazem

- History of asthma

Locations and Contacts

Rasoul-e-Akram Hospital, Tehran 14436151, Iran, Islamic Republic of
Additional Information

Starting date: February 2011
Last updated: July 30, 2012

Page last updated: August 23, 2015

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