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The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks

Information source: Loma Linda University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Total Knee Arthroplasty

Intervention: Ropivacaine (Drug); Dexamethasone (Drug); Dexamethasone (Drug); Normal Saline (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Loma Linda University

Official(s) and/or principal investigator(s):
Charles Lee, MD, Principal Investigator, Affiliation: Loma Linda University

Summary

Dexamethasone is a commonly used steroid. This medication has been used for many years by physicians for many different indications. Recent articles, multiple case reports, and experience at this institution have indicated that dexamethasone successfully prolongs the effective duration of local anesthetics for regional blocks. This can cause a significant reduction in postoperative pain and the decreased need for postoperative narcotics. Although other adjuncts can be used for prolonging nerve blocks, epinephrine causes local vasoconstriction which can cause ischemia and nerve damage in a large nerve such as the sciatic nerve. Dexamethasone will not cause this problem and yet could prolong the duration of a sciatic nerve block. Therefore, the goal of this study is to prospectively evaluate the effectiveness of dexamethasone, both locally through the nerve block and systemically via IV administration, in prolonging the effective duration of local anesthetics when used in sciatic nerve blocks.

Clinical Details

Official title: The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome: Duration of Sciatic Nerve Block

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age 18-80 yrs, male or female subjects.

- Subjects must be scheduled to undergo total knee arthroplasty under general

anesthesia with consent for a femoral and sciatic nerve block post operatively for pain control.

- American Society of Anesthesiology Class 1,2,3,or 4.

- Capable of speaking and understanding English sufficiently to provide written

informed consent and able to respond when asked.

- Weight > or equal to 60kg.

Exclusion Criteria:

- Any allergies or hypersensitivity to ropivacaine or dexamethasone.

- Subject is on chronic steroids preoperatively for any reason.

- History of chronic pain syndrome (i. e. CPRS, Lumbar radiculopathy).

- History of documented or stated nerve damage or neuropathy to the surgical lower

extremity.

- Contraindication to placement of sciatic nerve block.

- Sciatic block placement failure.

- Subject mistakenly receives steroids intraoperatively.

Locations and Contacts

Loma Linda University Medical Center, Loma Linda, California 92354, United States
Additional Information

Starting date: August 2007
Last updated: June 10, 2014

Page last updated: August 23, 2015

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