Treatment of Patients With Blepharitis and Facial Rosacea
Information source: CollaGenex Pharmaceuticals
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Blepharitis; Meibomianitis; Dry Eye
Intervention: doxycycline (Drug); placebo (Drug)
Phase: Phase 2
Status: Recruiting
Sponsored by: CollaGenex Pharmaceuticals Official(s) and/or principal investigator(s):
Angel Angelov, MD, Study Chair, Affiliation: CollaGenex Pharmaceuticals
Summary
To determine the safety and efficacy of sub-antimicrobial dose doxycycline in the treatment
of patients who have both blepharitis and facial rosacea
Clinical Details
Official title: Efficacy and Safety of COL-101 for the Treatment of Blepharitis in Patients With Facial Rosacea
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Parallel Assignment, Safety/Efficacy Study
Primary outcome: Change in Ocular Surface Disease Index
Change in bulbar conjunctival hyperemia
Secondary outcome: Change in Schirmer tear test at each study visit
Change in tear break-up time at each study visit
Change in meibum character/fluidity at each study visit
Change in meibomian gland inspissation at each study visit
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- blepharitis
- facial rosacea
Exclusion Criteria:
- pregnant or nursing women
- allergy to tetracyclines
- recent eye surgery
- past or current use of isotretinoin
- patients who are achlorhydric
- patients who have had gastric by-pass surgery
Locations and Contacts
Pleasant Valley Ophthalmology, Little Rock, Arkansas 72212, United States; Recruiting
Laurie Barber, M.D., Phone: 501-686-5150, Email: lbarber66@yahoo.com
Laurie Barber, M.D., Principal Investigator
Warren Scherer, MD, Naples, Florida 34103, United States; Recruiting
Warren Scherer, MD, Phone: 239-261-8383
Kentucky Lions Eye Center, Louisville, Kentucky 40202, United States; Recruiting
Xiamo Wang, Phone: 502-852-3826, Email: gnawomaix@gmail.com
Gary Foulks, MD, Principal Investigator
Washington University School of Medicine, St. Louis, Missouri 63110, United States; Recruiting
Adina O'Neal, Phone: 314-747-8014, Email: oneala@vision.wustl.edu
Andrew Huang, MD, Principal Investigator
Marguerite McDonald, MD, Lynbrook, New York 11563, United States; Recruiting
Carla Del Castillo, Phone: 516-593-4026
Dean McGee Eye Institute, Oklahoma City, Oklahoma 73104, United States; Recruiting
Misty Youngblood, Phone: 405-271-6307, Email: misty-youngblood@dmei.org
James Chodosh, MD, Principal Investigator
Anita Nevyas-Wallace, MD, Bala Cynwyd, Pennsylvania 19004, United States; Recruiting
Anita Nevyas-Wallace, MD, Phone: 610-668-2777
Tanner Clinic, Layton, Utah 84041, United States; Recruiting
Amanda Tinsley, Phone: 801-773-4840, Ext: 3741, Email: amandaetinsley@yahoo.com
Lance Nelson, MD, Principal Investigator
Additional Information
Starting date: November 2007
Ending date: October 2008
Last updated: April 16, 2008
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