Efficacy of Pre- and Post-Operative Oral Dextromethorphan

Condition(s) targeted: Efficacy of Dextromethorphan; Morphine Consumption; Pain

Intervention: pre-operatively followed by 30 mg three times per day after surgery (Drug)

Phase: N/A

Status: Completed

Sponsored by: Khon Kaen University

Official(s) and/or principal investigator(s):
waraporn chau-in, Asso Prof., Study Chair, Affiliation: Department of Anesthesiology, Faculty of Medicine,KhonKaen University,KhonKaen 40002, Thailand
BUSABONG SUKMOUEN, Dr., Principal Investigator, Affiliation: Department of Anesthesiology
KRIANGSAK NGAMSANGSIRISAPT, Dr., Principal Investigator, Affiliation: Department of Anesthesiology
WINITA JIRARAREUNGSAK, Principal Investigator, Affiliation: Department of Anesthesiology

We studied the effect of dextromethorphan (DEX), an N-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy. Our aim was to compare the analgesic effectiveness and incidence of adverse side effects of oral DEX with placebo (P)

Official title: Efficacy of Pre- and Post-Operative Oral Dextromethorphan for Reduction of Intra- and 24-Hr Post-Operative Morphine Consumption for Transabdominal Hysterectomy

Study design: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study

Primary outcome:

Mean morphine consumption

Mean pain score

Detailed description: One hundred patients were randomized to two groups. Group DEX was given 30 mg tablets of oral dextromethorphan with their pre-medication and three more times in the first 24 hours after surgery. Group P received the placebo following the same schedule. Post-operative analgesic requirements were assessed using a patient-controlled analgesia system.

Pain was assessed at rest using a visual analog scale in the post anesthetic care unit(PACU), 6 and 24 hours after surgery.

Minimum age: 30 Years. Maximum age: 60 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- women aged between 30 and 60, with an ASA physical status of I or II, undergoing elective total abdominal hysterectomy under general anesthesia.

Exclusion Criteria:

- Women with a history of significant renal or hepatic impairment, allergy to any of the study medications, antitussive or NSAID use (48 hours or 1 week, respectively) before surgery, chronic pain and regular analgesic use, were excluded. Patients taking medications that could interact with dextromethorphan, including quinidine, flecainide, mexiletine, fluoxetine, amitriptyline, nortriptyline, and propafenone

Waraporn Chau-in, KhonKaen 40002, Thailand

Starting date: December 2002
Ending date: December 2003
Last updated: September 12, 2005