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Blockade of Vascular Potassium Channels During Human Endotoxemia

Information source: Radboud University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Endotoxemia

Intervention: endotoxin (Drug); Potassium channel blockers: TEA, Quinin, Tolbutamide (Drug); L-NMMA (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: Radboud University

Official(s) and/or principal investigator(s):
Peter Pickkers, MD, PhD, Principal Investigator, Affiliation: Radboud University


Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Clinical Details

Official title: Blockade of Vascular Potassium Channels During Human Endotoxemia

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:


Markers of Inflammation


Markers of Renal Injury

Inducible NO synthase expression


Mediators of Vascular reactivity

Sensitivity to norepinephrine


Minimum age: 18 Years. Maximum age: 35 Years. Gender(s): Both.


Inclusion Criteria:

- healthy volunteers

Exclusion Criteria:

- drug, alcohol, nicotine abuse

Locations and Contacts

Additional Information

Starting date: January 2003
Last updated: October 16, 2008

Page last updated: August 23, 2015

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