Treatment of Cholestatic Pruritus With Sertraline
Information source: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pruritus; Liver Cirrhosis, Biliary; Hepatitis C
Intervention: sertraline (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Summary
The goal of this study is to find an effective and well-tolerated medical therapy for itching
due to liver disease. Persons with primary biliary cirrhosis or chronic hepatitis C are
currently being enrolled in the study. Persons participating in the study are given
sertraline, a medication which is also often used for depression,to treat their itching. The
dose is gradually increased as the effect on itching and any other potential side effects are
carefully monitored.
Clinical Details
Official title: Treatment of Cholestatic Pruritus With Sertraline
Study design: Treatment, Non-Randomized, Open Label, Dose Comparison, Single Group Assignment, Safety/Efficacy Study
Eligibility
Minimum age: 21 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
- Itching for at least 3 months
- Primary biliary cirrhosis or hepatitis C
- Elevated alkaline phosphatase for at least 6 months
Locations and Contacts
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States
Additional Information
Starting date: April 2003
Ending date: March 2005
Last updated: October 9, 2007
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