Discontinuation Order of Vasopressors in Septic Shock

Condition(s) targeted: Septic Shock

Intervention: Vasopressin (Drug); Norepinephrine (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Samsung Medical Center

Official(s) and/or principal investigator(s):
kyeongman Jeon, M.D., Ph.D., Principal Investigator, Affiliation: Samsung Medical Center

The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the treatment of septic shock.

Official title: Incidence of Hypotension Based on the Discontinuation Order of Vasopressors in the Management of Septic Shock

Study design: Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Supportive Care

Primary outcome: Incidence of hypotension

Secondary outcome:

Time of hypotension

Vasopressor free day

28-day mortality

ICU mortality

In-hospital mortality

Detailed description: There are little data regarding the discontinuation of vasopressors in patients with septic shock. Therefore, the investigators intend to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the treatment of septic shock.

Minimum age: 20 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients 20 years of age or older

- patients of receiving concomitant therapy with norepinephrine and vasopressin for

teh management of septic shock

- patients began to reduce the vasopressor

Exclusion Criteria:

- patients who expired or had care withdrawn while receiving norepinephrine and

vasopressin

- patients being transferred into the ICU from an outside facility or the operating

room

- patients who are suspected to have vasopressin deficiency (eg. HPA axis dysfunction,

empty sella)

- acute myocardial infarction or Congestive heart failure (NYHA functional

classification III or IV)

- acute mesenteric ischemia

- patients who were received other vasopressor except for norepinephrine or vasopressin

Samsung Medical Center, Seoul 135-710, Korea, Republic of

Starting date: December 2011
Last updated: January 28, 2015