Aldosterone in Diabetic Nephropathy
Information source: Universidad Los Andes
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Diabetic Nephropathy
Intervention: Spironolactone (Drug); Placebo (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Universidad Los Andes Overall contact:
Francisco G Espinoza, MD, Phone: 56 - 2 -91380529, Ext: 000, Email: fespinoz@mi.cl
Summary
The purpose of this study is to determine whether spironolactone are effective in the
reduction of albuminuria and diastolic disfunction of subjects with diabetic nephropathy.
Clinical Details
Official title: Effect of Aldosterone Antagonism in the Reduction of Albuminuria and Diastolic Disfunction of Patients With Diabetic Nephropathy.
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Parallel Assignment, Safety/Efficacy Study
Primary outcome: Reduction of albuminuria
Secondary outcome: Reduction of diastolic disfunction
Eligibility
Minimum age: 30 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Diabetic subjects with maximum ten years after diagnostic
- Diabetic nephropathy with albuminuria
- Normal renal function
- Diastolic disfunction
- Taking a IECA or ARA drug family previously
Exclusion Criteria:
- Diabetics subjects with macroangiopathy
- Acute coronary syndrome in the three months before
- Hyperkalemia > 5. 5 mEq/L
- Pregnancy
Locations and Contacts
Francisco G Espinoza, MD, Phone: 56 - 2 -91380529, Ext: 000, Email: fespinoz@mi.cl
University of Los Andes, Santiago 762000, Chile; Recruiting
Helia M Morales, MD, Phone: 56 - 2 - 93381451, Ext: 000, Email: heliamorales@gmail.com
Francisco G Espinoza, MD, Principal Investigator
Additional Information
Related publications: Kozie DW, Hassul M, Kimm J. Effect of tympanic membrane perforations on air caloric response in monkeys. Trans Sect Otolaryngol Am Acad Ophthalmol Otolaryngol. 1976 Mar-Apr;82(2):203-9. No abstract available.
Starting date: March 2009
Ending date: March 2010
Last updated: March 25, 2009
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