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The Effect of Chloroquine in the Treatment of Patients With Dengue

Information source: University of Sao Paulo
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Dengue

Intervention: Placebo (Drug); Chloroquine (Drug)

Phase: Phase 1/Phase 2

Status: Active, not recruiting

Sponsored by: University of Sao Paulo

Official(s) and/or principal investigator(s):
Benedito AL Fonseca, PhD, Principal Investigator, Affiliation: São Paulo University Medical School at Ribeirão Preto


The objective of this study was to evaluate the effect of chloroquine in the treatment of patients with dengue.

Clinical Details

Official title: The Effect of Chloroquine in the Treatment of Patients With Dengue

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Duration of the disease

Secondary outcome: Intensity and days of fever and symptoms


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Patients suspected of having dengue disease

- Patients were included in the study if they presented with fever and at least two

other symptoms, such as:

- headache

- pain behind the eyes

- muscle and bone or joint pains

- nausea

- vomiting

- rash associated to dengue for less than 72 hours

Exclusion Criteria:

- Pregnant

- Younger than 18-years old

- Either cardiac or neurologic disease

Locations and Contacts

São Paulo University Medical School at Ribeirão Preto, Ribeirão Preto, SP 14048.900, Brazil
Additional Information

Starting date: February 2008
Last updated: February 23, 2009

Page last updated: August 20, 2015

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