DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets

Information source: National Center for Research Resources (NCRR)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Congenital Adrenal Hyperplasia

Intervention: Nifedipine (Drug)

Phase: Phase 1/Phase 2

Status: Completed

Sponsored by: National Center for Research Resources (NCRR)

Summary

This study will test the ability of extended release nifedipine (Procardia XL), a blood pressure medication, to permit a decrease in the dose of glucocorticoid medication children take to treat congenital adrenal hyperplasia (CAH).

Clinical Details

Study design: Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Detailed description: This protocol is designed to assess both acute and chronic effects of the calcium channel antagonist, nifedipine, on the hypothalamic-pituitary-adrenal axis in patients with congenital adrenal hyperplasia. The multicenter trial is composed of two phases and will involve a double-blind, placebo-controlled parallel design. The goal of Phase I is to examine the ability of nifedipine vs. placebo to decrease adrenocorticotropic hormone (ACTH) levels, as well as to begin to assess the dose-dependency of nifedipine effects. The goal of Phase II is to evaluate the long-term effects of nifedipine; that is, can attenuation of ACTH release by nifedipine permit a decrease in the dosage of glucocorticoid needed to suppress the HPA axis? Such a decrease would, in turn, reduce the deleterious effects of glucocorticoid treatment in CAH.

Eligibility

Minimum age: 14 Years. Maximum age: 35 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- diagnosed with Congenital Adrenal Hyperplasia (CAH)

- normal ECG during baseline evaluation

Exclusion Criteria:

- history of liver disease, or elevated liver function tests

- history of cardiovascular disease

Locations and Contacts

Medical University of South Carolina, Charleston, South Carolina, United States
Additional Information


Last updated: June 23, 2005

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017