Electroconvulsive Therapy in Clozapine-resistant Schizophrenia
Information source: Niuvanniemi Hospital
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Schizophrenia; Schizoaffective Disorder
Intervention: electroconvulsive therapy (Device)
Phase: N/A
Status: Recruiting
Sponsored by: Niuvanniemi Hospital Overall contact: Eila Tiihonen, MD, PhD, Phone: +358 295 242 204, Email: eila.tiihonen@niuva.fi
Summary
Electroconvulsive therapy (ECT) is one of the oldest neuromodulation treatments still used
in psychiatry. Only case reports and open label non-randomized studies have been published
of ECT in clozapine-resistant schizophrenia patients. The purpose of this trial is to study
the efficacy and cognitive effects of add-on ECT treatment (10-course) in schizophrenia
patients taking clozapine.
Clinical Details
Official title: Efficacy and Cognitive Effects of Electroconvulsive Therapy in Clozapine-Resistant Schizophrenia
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Primary outcome: Positive and Negative Symptom Scale
Eligibility
Minimum age: 18 Years.
Maximum age: 64 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- diagnosis of schizophrenia or schizoaffective disorder
- treatment-resistant to clozapine
- age 18 - 64 years
- capacity and willingness to give informed consent
Exclusion Criteria:
- serious somatic illness
- progressive neurological illness, recent brain damage or sequela of serious brain
damage
- ECT less than 3 months prior to this trial
Locations and Contacts
Eila Tiihonen, MD, PhD, Phone: +358 295 242 204, Email: eila.tiihonen@niuva.fi
Niuvanniemi Hospital, Kuopio, Finland; Recruiting Soile Hyvärinen, MD, Phone: +358 295 242 219, Email: soile.hyvarinen@niuva.fi Soile Hyvärinen, MD, Sub-Investigator Eila Tiihonen, MD, PhD, Principal Investigator
Additional Information
Starting date: June 2014
Last updated: June 5, 2014
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