The purpose of this study is to study how the body processes digoxin and the effect of
dulaglutide on how digoxin is processed by the body. Information about any side effects that
may occur will also be collected.
This study is for research purposes only and is not intended to treat any medical condition.
This research study requires that a blood sample be obtained and stored for future research
involving genetic analysis.
Inclusion Criteria:
- are overtly healthy males or females, as determined by medical history and physical
examination
- male subjects with female partners of child-bearing potential, or partners who are
pregnant or breastfeeding, agree to use a reliable method of contraception from the
time of the first dose until 3 months after the last dose of investigational product,
as determined by the investigator. The method may be one of the following:
- condom with spermicidal agent
- male subject sterilization
- true abstinence (which is in line with the subject's usual lifestyle choice;
withdrawal or calendar methods are not considered acceptable)
- female subjects not of child-bearing potential (i. e. are postmenopausal or
permanently sterilized [e. g. tubal occlusion, hysterectomy, bilateral
salpingectomy]). Such subjects will not be required to use contraception but must
test negative for pregnancy at the time of enrolment Postmenopausal is defined as at
least 1 year post cessation of menses (without an alternative medical cause) or at
least 1 year of spontaneous amenorrhea, with follicle stimulating hormone (FSH) ≥40
mIU/mL
- female subjects who have undergone sterilization by tubal ligation: agree to use a
condom in conjunction with spermicidal gel, foam, cream, film or suppository from the
time of screening until 3 months after the last dose of investigational product. Such
subjects must also test negative for pregnancy at the time of enrolment
- have a body mass index (BMI) of 18. 5 to 32. 0 kg/m2, inclusive, at screening
- have clinical laboratory test results within normal reference range for the
population or investigator site, or results with acceptable deviations that are
judged to be not clinically significant by the investigator (potassium, magnesium,
and calcium values must be within the normal range)
- have normal renal function defined as an estimated creatinine clearance (CrCl) of ≥80
mL/min
- have venous access sufficient to allow for blood sampling
- are reliable and willing to make themselves available for the duration of the study
and are willing to follow study restrictions
- have given written informed consent approved by Lilly and the ethical review board
(ERB) governing the site
Exclusion Criteria:
- are currently enrolled in, have completed or discontinued within the last 30 days
from, a clinical trial involving an investigational product, or are concurrently
enrolled in any other type of medical research judged not to be scientifically or
medically compatible with this study
- have known allergies to glucagon like peptide -1 (GLP-1)-related compounds including
dulaglutide or to digoxin, related compounds or any components of either formulation
- are persons who have previously completed or withdrawn from this study or any other
study investigating dulaglutide in the 3 months prior to screening or have received
glucagon-like peptides or incretin mimetics in the 3 months prior to screening have
an abnormality in the 12-lead electrocardiogram (ECG) (e. g. first, second, or third
degree atrioventricular (AV) block, prolonged QTc interval, sinus tachycardia, sinus
bradycardia, atrial fibrillation, or sinus node disease) that, in the opinion of the
investigator, increases the risks associated with participating in the study
- have a history of significant dysrhythmias or AV block.
- have an abnormal blood pressure (after at least 5 minutes sitting) that, in the
opinion of the investigator, increases the risks associated with participating in the
study
- have a history or presence of cardiac, respiratory, hepatic, renal, endocrine (e. g.
hypothyroidism), hematological, or neurological disorders capable of significantly
altering the absorption, metabolism, or elimination of drugs; of constituting a risk
when taking the study medication; or of interfering with the interpretation of data
- have a history or presence of pancreatitis (history of chronic pancreatitis or
idiopathic acute pancreatitis) or gastrointestinal disorder, for example relevant
esophageal reflux or gall bladder disease, or any gastrointestinal disease which
impacts gastric emptying (GE) (e. g. gastric bypass surgery, pyloric stenosis, with
the exception of appendectomy) or could be aggravated by glucagon like peptide-1
(GLP-1) analogs. Subjects with dyslipidemia, and subjects who had cholecystolithiasis
(removal of gall stones) and/or cholecystectomy (removal of gall bladder) in the
past, with no further sequelae.
- show evidence of significant active neuropsychiatric disease
- have family history of medullary thyroid cancer (MTC) or a genetic condition that
predisposes to MTC
- regularly use known drugs of abuse and/or show positive findings on urinary drug
screening
- show evidence of human immunodeficiency virus (HIV) infection and/or positive human
HIV antibodies
- show evidence of hepatitis C and/or positive hepatitis C antibody
- show evidence of hepatitis B and/or positive hepatitis B surface antigen
- are women with a positive pregnancy test or women who are lactating
- have used or intend to use over-the-counter medication other than acetaminophen
within 7 days prior to dosing or prescription medication (with the exception of
vitamin/mineral supplements) within 14 days prior to dosing, or have used St John's
Wort within 14 days prior to dosing
- have donated blood of more than 500 mL within the month prior to screening and 14
units per week (females), or are unwilling to stop alcohol consumption from screening
through follow-up (1 unit = 12 oz or 360 mL of beer; 5 oz or 150 mL of wine; 1. 5 oz
or 45 mL of distilled spirits)
- are smokers
- have a history of cancer with the past 20 years, with the exception of basal cell or
squamous cell skin cancer, or treated cervical carcinoma in situ
- intend to consume grapefruit within 7 days prior to dosing
- are subjects who, in the opinion of the investigator, are in any way unsuitable to
participate in the study
- have any medical conditions, medical history or are taking any medication which are
contraindicated
There is only one site in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or, Phone: 1-317-615-4559
