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Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Information source: University of Erlangen-Nürnberg Medical School
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Primary Hypertension

Intervention: spironolactone (Drug); placebo (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: University of Erlangen-Nürnberg Medical School

Official(s) and/or principal investigator(s):
Roland E Schmieder, MD, FACP, Principal Investigator, Affiliation: Universität Erlangen-Nurnberg


The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

Clinical Details

Official title: Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: left ventricular mass


Minimum age: 18 Years. Maximum age: 40 Years. Gender(s): Male.


Inclusion Criteria:

- Clinical diagnosis hypertension (BP higher than 139/89)

Exclusion Criteria:

- Antihypertensive pretreatment

- Contraindications against spironolactone

- Being unable to understand or comply with study procedures

Locations and Contacts

University Erlangen-Nürnberg, Nephrology and Hypertension, Erlangen 91054, Germany
Additional Information

Starting date: March 2008
Last updated: July 6, 2012

Page last updated: August 23, 2015

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