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Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma

Information source: University of Rostock
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Allergic Asthma

Intervention: Salmeterol and Salmeterol / Fluticasone (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Rostock

Official(s) and/or principal investigator(s):
Johann C. Virchow, MD, FCCP, Study Chair, Affiliation: University of Rostock

Summary

BDNF has been linked to the pathogenesis of airway hyperresponsiveness in asthma. In this trial, the impact of a treatment with salmeterol and salmeterol / fluticasone on BDNF concentrations will be assessed in patients with asthma. The investigators hypothesize that salmeterol impacts on BDNF concentrations in patients with asthma.

Clinical Details

Official title: Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: BDNF concentrations in serum, platelets and plasma

Secondary outcome: Airway hyperresponsiveness

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age > 18 years, a physician's diagnosis of allergic asthma

- A documented sensitization to aero-allergens (pollen, animal hair, or house dust

mite)

- A pre-bronchodilator forced expiratory volume in the first second (FEV1) > 80 % of

the predicted value (% predicted), a provocative concentration of histamine causing a 20 % fall in FEV1 (PC20) of < 8 mg histamine / ml Exclusion Criteria:

- No regular treatment (only short-acting inhalers on demand were allowed)

- No history of or evidence for any other chronic disease than asthma

- No history of smoking, absence of any signs or symptoms of an infection

Locations and Contacts

University of Rostock, Rostock 18057, Germany
Additional Information

Related publications:

Lommatzsch M, Schloetcke K, Klotz J, Schuhbaeck K, Zingler D, Zingler C, Schulte-Herbrüggen O, Gill H, Schuff-Werner P, Virchow JC. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. Am J Respir Crit Care Med. 2005 Jan 15;171(2):115-20. Epub 2004 Oct 29.

Starting date: September 2005
Last updated: August 20, 2008

Page last updated: August 23, 2015

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