Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
Information source: University of Rostock
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Allergic Asthma
Intervention: Salmeterol and Salmeterol / Fluticasone (Drug)
Phase: N/A
Status: Completed
Sponsored by: University of Rostock Official(s) and/or principal investigator(s): Johann C. Virchow, MD, FCCP, Study Chair, Affiliation: University of Rostock
Summary
BDNF has been linked to the pathogenesis of airway hyperresponsiveness in asthma. In this
trial, the impact of a treatment with salmeterol and salmeterol / fluticasone on BDNF
concentrations will be assessed in patients with asthma. The investigators hypothesize that
salmeterol impacts on BDNF concentrations in patients with asthma.
Clinical Details
Official title: Effect of Salmeterol on Brain-Derived Neurotrophic Factor (BDNF) Concentrations in Asthma
Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: BDNF concentrations in serum, platelets and plasma
Secondary outcome: Airway hyperresponsiveness
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age > 18 years, a physician's diagnosis of allergic asthma
- A documented sensitization to aero-allergens (pollen, animal hair, or house dust
mite)
- A pre-bronchodilator forced expiratory volume in the first second (FEV1) > 80 % of
the predicted value (% predicted), a provocative concentration of histamine causing a
20 % fall in FEV1 (PC20) of < 8 mg histamine / ml
Exclusion Criteria:
- No regular treatment (only short-acting inhalers on demand were allowed)
- No history of or evidence for any other chronic disease than asthma
- No history of smoking, absence of any signs or symptoms of an infection
Locations and Contacts
University of Rostock, Rostock 18057, Germany
Additional Information
Related publications: Lommatzsch M, Schloetcke K, Klotz J, Schuhbaeck K, Zingler D, Zingler C, Schulte-Herbrüggen O, Gill H, Schuff-Werner P, Virchow JC. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. Am J Respir Crit Care Med. 2005 Jan 15;171(2):115-20. Epub 2004 Oct 29.
Starting date: September 2005
Last updated: August 20, 2008
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