Doxycycline for Lateral Epicondylalgia - RCT
Information source: Kaunas University of Medicine
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Lateral Epicondylalgia (Tennis Elbow)
Intervention: Placebo (Drug); Doxycycline (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Kaunas University of Medicine Overall contact:
Alfredas Smailys, MD, PhD, Phone: +370 37 327201, Email: smailys@takas.lt
Summary
Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a
widely available pharmaceutical agent mostly used for its antibiotic properties, also
functions as an inhibitor of MMPs.
This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia
(tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily,
or placebo. Main outcome variable is pain (VAS) at three weeks.
Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of
metalloproteinases are measured.
Clinical Details
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: Pain (VAS)
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age 18-65
- Pain at the lateral side of the elbow ≥8 weeks
- Local tenderness on palpation of the lateral epicondyle
- Pain on resisted extension of the wrist
Exclusion Criteria:
- Rheumatic disorder
- History of fibromyalgia or generalised pain
- Elbow surgery (on the painful side)
- Active infection
- Glucocorticoid treatment during the duration of symtoms of epicondylalgia
- NSAID use within 1 w before presentation and during the study
- Pregnancy
- Taking drug that might interact with doxycycline
Locations and Contacts
Alfredas Smailys, MD, PhD, Phone: +370 37 327201, Email: smailys@takas.lt
Dept of Orthopaedics, Kaunas Medical University, Kaunas, Lithuania; Recruiting
Alfredas Smailys, Email: smailys@takas.lt
Additional Information
Last updated: February 27, 2008
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