DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Chart Review of Antivirals for Influenza in Infants

Information source: National Institute of Allergy and Infectious Diseases (NIAID)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Influenza

Phase: N/A

Status: Completed

Sponsored by: National Institute of Allergy and Infectious Diseases (NIAID)

Summary

This retrospective study conducted in Canada and the US involves a chart review to assess the safety of oseltamivir (TamifluŽ) compared to alternate antiviral therapy, amantidine or rimantidine, administered to children less than 12 months of age with diagnosed or suspected influenza. The objectives are to describe the frequency of neurological and all other adverse events possibly related to administration of these antivirals in these infants. Investigators will also compare frequency of adverse events at various doses of oseltamivir in these children. Critical endpoints to be collected include frequency and severity of adverse events, particularly those relating to central nervous system complications. A sub-investigator will travel to each of the participating sites to collect data related to each infant's health prior to becoming ill, health status at time of influenza diagnosis, dosing regimen, reported neurological events post-dosing, and all reported adverse events post-dosing.

Clinical Details

Official title: A Retrospective Chart Review to Assess the Safety of Oseltamivir (TamifluŽ) Compared to Alternate Antiviral Therapy (Amantadine or Rimantadine) Administered to Children Less Than 12 Months of Age With Diagnosed or Suspected Influenza (CASG 113)

Study design: Time Perspective: Retrospective

Detailed description: The study is a retrospective review of charts of children less than 12 months of age that were diagnosed with influenza and treated with oseltamivir. The chart review will focus on assessment of neurological and other adverse events that may have been related to the administration of oseltamivir. A control population will consist of children less than 12 months treated with either rimantadine or amantadine. The administration of oseltamivir to children at high risk (i. e. immunocompromised hosts) less than 12 months old with influenza is frequently considered in medical practice despite the findings of neurotoxicity in a juvenile rat study. Since oseltamivir is the only active treatment against H5N1 influenza strains, it is imperative to understand the ramifications of its potential widespread use in very young infants in the event of an outbreak. This study is designed to gather documented evidence by which the circumstances of use and defined outcomes can be described. Patient selection will be made by review of hospital inpatient medical records, emergency room medical records and/or pharmacy records to identify patients less than 1 yr old dosed with oseltamivir suspension. Redacting the charts will be done in a manner that will obscure personal health information (individual identifiers) without obscuring the necessary clinical data. A separate research data collection form will be prepared on which critical information can be transcribed that would subsequently be available for analysis. Critical information to be captured at the time of initiating oseltamivir treatment includes: age, birth history, gender, underlying medical conditions, presenting influenza symptoms, if done, type of flu test and dose regime. Critical endpoints to be collected will include the frequency and severity of adverse events, particularly those relating to central nervous system complications.

Eligibility

Minimum age: N/A. Maximum age: 11 Months. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Male or female study participants less than 12 months of age 2. Suspected or laboratory diagnosis of influenza 3. Treated with oseltamivir, rimantadine or amantadine Exclusion Criteria: None listed

Locations and Contacts

University of Alabama at Birmingham, Birmingham, Alabama 35233-0011, United States

University of Alberta, Edmonton, Alberta T6G 2B7, Canada

Arkansas Children's Hospital, Pulaski, Arkansas 72202, United States

Children's Hospital of Orange County, Orange, California 92868, United States

Children's Hospital and Health Center, San Diego, California 92123, United States

University of Colorado, Denver, Colorado 80218, United States

Washington University in St. Louis, Saint Louis, Missouri 63110, United States

Creighton University, Omaha, Nebraska 68198-2162, United States

MetroHealth Medical Center, Cleveland, Ohio 44109, United States

Oregon Health Sciences University, Portland, Oregon 97201-3098, United States

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States

The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9063, United States

Cook Children's Medical Center, Fort Worth, Texas 76104, United States

The University of Texas Health Science Center, San Antonio, Texas 78229-3900, United States

University of Utah, Salt Lake City, Utah 84132, United States

Seattle Children's Hospital, Seattle, Washington 98105, United States

Additional Information

Starting date: November 2005
Last updated: May 12, 2011

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017