Information source: Yale University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Diabetes; Retinopathy; Vascular Pathology
Intervention: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin (Device)
Sponsored by: Yale University
Official(s) and/or principal investigator(s):
David G Silverman, Principal Investigator, Affiliation: Yale School of Medicine
This study attempts to test capillary responses to various challenges without the need for
iontophoresis (electrical current).
Official title: Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.
Study design: Screening, Cross-Sectional, Defined Population, Prospective Study
Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug
absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting
to create tests of the microvasculature that do not require iontophoretic drug delivery.
Minimum age: 18 Years.
Maximum age: N/A.
Inclusion Criteria: diabetic. -
Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.
Locations and Contacts
Yale School of Medicine, New HAven, Connecticut 06510, United States
Starting date: June 2005
Ending date: September 2005
Last updated: October 5, 2006