Microvascular Reactivity.
Information source: Yale University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Diabetes; Retinopathy; Vascular Pathology
Intervention: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin (Device)
Phase: N/A
Status: Completed
Sponsored by: Yale University Official(s) and/or principal investigator(s):
David G Silverman, Principal Investigator, Affiliation: Yale School of Medicine
Summary
This study attempts to test capillary responses to various challenges without the need for
iontophoresis (electrical current).
Clinical Details
Official title: Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.
Study design: Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional
Detailed description:
Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug
absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting
to create tests of the microvasculature that do not require iontophoretic drug delivery.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria: diabetic. -
Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.
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Locations and Contacts
Yale School of Medicine, New HAven, Connecticut 06510, United States
Additional Information
Starting date: June 2005
Last updated: October 5, 2006
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