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Microvascular Reactivity.

Information source: Yale University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Diabetes; Retinopathy; Vascular Pathology

Intervention: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin (Device)

Phase: N/A

Status: Completed

Sponsored by: Yale University

Official(s) and/or principal investigator(s):
David G Silverman, Principal Investigator, Affiliation: Yale School of Medicine


This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Clinical Details

Official title: Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Study design: Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Detailed description: Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.


Locations and Contacts

Yale School of Medicine, New HAven, Connecticut 06510, United States
Additional Information

Starting date: June 2005
Last updated: October 5, 2006

Page last updated: August 23, 2015

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