Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections
Information source: National Center for Complementary and Alternative Medicine (NCCAM)
Information obtained from ClinicalTrials.gov on March 21, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Urinary Tract Infections
Intervention: Cranberry juice (Drug); Amoxicillin (Drug)
Phase: N/A
Status: Completed
Sponsored by: National Center for Complementary and Alternative Medicine (NCCAM) Official(s) and/or principal investigator(s):
Gail D Anderson, PhD, Principal Investigator, Affiliation: University of Washington
Summary
The purpose of study is to determine whether cranberry juice interacts with antibiotics used
to treat urinary tract infections (UTIs).
Clinical Details
Official title: Cranberry: Interactions With Anti-Infectious Agents
Study design: Treatment, Non-Randomized, Open Label, Active Control, Crossover Assignment, Pharmacokinetics Study
Primary outcome: Drug Elmination
Secondary outcome: Drug absorption
Detailed description:
Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent
urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may
affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study
will determine whether concurrent cranberry juice administration lowers the urinary
concentrations of two commonly used antibiotics, amoxicillin and cefaclor.
This study will involve children being treated for UTIs and adults without UTIs. All of the
children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days of
antibiotic treatment, the children will be assigned to receive either cranberry juice for 2
days or no additional treatment. Urine samples will be collected from all child participants
before and after the administration of cranberry juice to examine the excretion of the
antibiotics.
Adult participants will receive two different doses of amoxicillin, with or without cranberry
juice. Blood and urine samples will be collected to evaluate the effect of cranberry juice on
the absorption and elimination of amoxicillin.
Eligibility
Minimum age: 6 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria for Children:
- Urinary tract infection (UTI) treated with cefaclor or amoxicillin
Inclusion Criteria for Adults:
- No UTI
Exclusion Criteria:
- Allergies to antibiotics
- Use of medications other than oral contraceptives
- Pregnancy or breast-feeding
- Smoker
Locations and Contacts
University of Washington, Seattle, Washington 98195, United States
Additional Information
Starting date: July 2006
Ending date: June 2007
Last updated: November 28, 2006
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